TY - JOUR
T1 - Determinants of Cross-Sectional and Longitudinal Health-Related Quality of Life in Memory Clinic Patients Without Dementia
AU - Banning, Leonie C. P.
AU - Janssen, Eveline P. C. J.
AU - Hamel, Renske E. G.
AU - de Vugt, Marjolein
AU - Kohler, Sebastian
AU - Wolfs, Claire A. G.
AU - Oosterveld, Saskia M.
AU - Melis, Rene J. F.
AU - Rikkert, Marcel G. M. Olde
AU - Kessels, Roy P. C.
AU - Pijnenburg, Yolande A. L.
AU - Koene, Ted
AU - van der Flier, Wiesje M.
AU - Scheltens, Philip
AU - Visser, Pieter Jelle
AU - Verhey, Frans R. J.
AU - Aalten, Pauline
AU - Ramakers, Inez H. G. B.
N1 - Funding Information:
The authors thank Nico Rozendaal for his help with the design of the database and data management of the 4C-study. Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was performed within the framework of the Clinical Course of Cognition and Comorbidity in MCI (4C-MCI) Study and was funded by Alzheimer Nederland (grant number: 20083494). ORCID iD Leonie C. P. Banning https://orcid.org/0000-0003-1437-5009 Supplemental Material Supplemental material for this article is available online.
Publisher Copyright:
© The Author(s) 2019.
PY - 2020/9
Y1 - 2020/9
N2 - Objective: To identify determinants within 3 different domains (ie, somatic comorbidities, cognitive functioning, and neuropsychiatric symptoms [NPS]) of health-related quality of life (HRQoL) over time in memory clinic patients without dementia. Methods: This longitudinal multicenter cohort study with a 3-year observation period recruited 315 individuals (age: 69.8 +/- 8.6, 64.4% males, Mini-Mental State Examination score 26.9 +/- 2.6). A multivariable explanatory model was built using linear mixed effects models (forward selection per domain) to select determinants for self-perceived HRQoL over time, as measured by the EuroQoL-5D visual analogue scale (EQ VAS). Results: Mean HRQoL at study entry was 69.4 +/- 15.6. The presence of agitation, appetite and eating abnormalities, and eyes/ears/nose (ie, sensory impairment) comorbidities were associated with a change in HRQoL over time. Agitation was most strongly associated with HRQoL over time. Conclusions: The association of somatic comorbidities and NPS in memory clinic patients with course of HRQoL shows that these should receive more awareness, detection, and monitoring by clinicians.
AB - Objective: To identify determinants within 3 different domains (ie, somatic comorbidities, cognitive functioning, and neuropsychiatric symptoms [NPS]) of health-related quality of life (HRQoL) over time in memory clinic patients without dementia. Methods: This longitudinal multicenter cohort study with a 3-year observation period recruited 315 individuals (age: 69.8 +/- 8.6, 64.4% males, Mini-Mental State Examination score 26.9 +/- 2.6). A multivariable explanatory model was built using linear mixed effects models (forward selection per domain) to select determinants for self-perceived HRQoL over time, as measured by the EuroQoL-5D visual analogue scale (EQ VAS). Results: Mean HRQoL at study entry was 69.4 +/- 15.6. The presence of agitation, appetite and eating abnormalities, and eyes/ears/nose (ie, sensory impairment) comorbidities were associated with a change in HRQoL over time. Agitation was most strongly associated with HRQoL over time. Conclusions: The association of somatic comorbidities and NPS in memory clinic patients with course of HRQoL shows that these should receive more awareness, detection, and monitoring by clinicians.
KW - health-related quality of life
KW - somatic comorbidities
KW - cognitive functioning
KW - neuropsychiatric symptoms
KW - subjective cognitive decline
KW - mild cognitive impairment
KW - MILD COGNITIVE IMPAIRMENT
KW - FUNCTIONAL GASTROINTESTINAL DISORDERS
KW - PARTICIPANTS AGED 24-81
KW - NORMATIVE DATA
KW - FOLLOW-UP
KW - NEUROPSYCHIATRIC SYMPTOMS
KW - ALZHEIMER-DISEASE
KW - OLDER-ADULTS
KW - PEOPLE
KW - EDUCATION
U2 - 10.1177/0891988719882104
DO - 10.1177/0891988719882104
M3 - Article
C2 - 31645191
SN - 0891-9887
VL - 33
SP - 256
EP - 264
JO - Journal of Geriatric Psychiatry and Neurology
JF - Journal of Geriatric Psychiatry and Neurology
IS - 5
M1 - 0891988719882104
ER -