Detection of Bone Marrow Edema Pattern With Dual-Energy Computed Tomography of the Pig Mandible Treated With Radiotherapy and Surgery Compared With Magnetic Resonance Imaging

Lucas J. Poort*, Annika A. R. Stadler, Johan H. B. Ludlage, Frank J. P. Hoebers, Peter A. W. H. Kessler, Alida A. Postma

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)

Abstract

Objective: The aim of the study was to investigate the accuracy of dual-energy computed tomography (DECT) compared with magnetic resonance (MR) imaging for the detection of edema of the mandible.

Materials and methods: Fifteen adult Gottingen mini pigs received irradiation to the mandible with an equivalent dose of 0, 25, 50, or 70 Gy. Six months after irradiation, all animals underwent DECT and MR imaging of the mandible. Magnetic resonance short tau inversion recovery (STIR) was used for the grading of the bone marrow edema (0-3). Dual-energy CT (80 and 140 kVp) was performed, and virtual noncalcium (VNCa) images were calculated.

Results: Increased signal intensity at STIR was found in the higher radiation groups. An increase of signal intensity in MR imaging was accompanied by a significant increase in the Hounsfield unit value of the VNCa images of the bone marrow (STIR: 0, 1, 2, 3; mean Hounsfield unit: -103, -90, -76, -34, respectively; P <0.05; R-2 = 0.388).

Conclusions: The VNCa images derived from DECT are able to demonstrate bone marrow edema in radiation-induced bone changes in the mandible.

Original languageEnglish
Pages (from-to)553-558
Number of pages6
JournalJournal of Computer Assisted Tomography
Volume41
Issue number4
DOIs
Publication statusPublished - 2017

Keywords

  • irradiation changes of the mandible
  • animal experiment
  • comparing DECT scan with MR imaging
  • virtual noncalcium images
  • VIRTUAL NONCALCIUM TECHNIQUE
  • CT
  • LESIONS
  • OSTEORADIONECROSIS
  • REDUCTION

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