Detection and Quantification by Deformation Imaging of the Functional Impact of Septal Compared to Free Wall Preexcitation in the Wolff-Parkinson-White Syndrome

Bart W. L. De Boeck*, Arco J. Teske, Geert E. Leenders, Firdaus A. A. Mohamed Hoesein, Peter Loh, Vincent J. van Driel, Pieter A. Doevendans, Frits W. Prinzen, Maarten Jan Cramer

*Corresponding author for this work

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Pacing experiments in healthy animal hearts have suggested a larger detrimental effect of septal compared to free wall preexcitation. We investigated the intrinsic relation among the site of electrical preexcitation, mechanical dyssynchrony, and dysfunction in human patients. In 33 patients with Wolff-Parkinson-White (WPW) syndrome and 18 controls, regional myocardial deformation was assessed by speckle tracking mapping (ST-Map) to assess the preexcitation site, shortening sequences and dyssynchrony, and the extent of local and global ejecting shortening. The ST-Map data in patients with accessory atrioventricular pathways correctly diagnosed as located in the interventricular septum (IVS) (n = 11) or left ventricular free wall (LFW) (n = 12) were compared to the corresponding control values. A local ejecting shortening of
Original languageEnglish
Pages (from-to)539-546
JournalAmerican Journal of Cardiology
Issue number4
Publication statusPublished - 15 Aug 2010

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