Detecting recurrent head and neck cancer using electronic nose technology: A feasibility study

Rens M. G. E. van de Goor*, Joey C. A. Hardy, Michel R. A. van Hooren, Bernd Kremer, Kenneth W. Kross

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Web of Science)

Abstract

Background The aim of this feasibility study was to assess the diagnostic performance of an electronic nose (e-nose) as a noninvasive diagnostic tool in detecting locoregional recurrent and/or second (or third) primary head and neck squamous cell carcinoma (HNSCC) after curative treatment. Methods Using an e-nose (Aeonose, The eNose Company, Zutphen, The Netherlands), breath samples were collected from patients after curative treatment of an HNSCC with a locoregional recurrence or second (or third) primary tumor (N = 20) and from patients without evidence of recurrent disease (N = 20). Analyses were performed utilizing artificial neural networking based on patterns of volatile organic compounds. Results A diagnostic accuracy of 83% was observed in differentiating follow-up patients with locoregional recurrent or second (or third) primary HNSCC from those without evidence of disease. Conclusion This study has demonstrated the feasibility of using an e-nose to detect locoregional recurrent and/or second (or third) primary HNSCC.

Original languageEnglish
Pages (from-to)2983-2990
Number of pages8
JournalHead and Neck-Journal for the Sciences and Specialties of the Head and Neck
Volume41
Issue number9
DOIs
Publication statusPublished - Sep 2019

Keywords

  • diagnostics
  • electronic nose
  • head and neck squamous cell carcinoma
  • recurrent head and neck cancer
  • volatile organic compounds
  • VOLATILE ORGANIC-COMPOUNDS
  • CELL CARCINOMA
  • LARYNGEAL
  • RADIOTHERAPY
  • MECHANISMS
  • DIAGNOSIS
  • TUMORS

Cite this