Details matter: the role of genomic location and assay standardization in DNA methylation analyses

Guro E. Lind*, Manon van Engeland

*Corresponding author for this work

Research output: Contribution to journalEditorialAcademicpeer-review

Abstract

Only when including quality and standardization at every level of DNA methylation analyses, will we be able to achieve the robustness to independently validate DNA methylation analyses and to compare multiple methylation studies in systematic reviews. This is the only way to more efficiently develop future DNA methylation based biomarkers.

Original languageEnglish
Pages (from-to)933-935
Number of pages3
JournalEpigenomics
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 2017

Keywords

  • biomarkers
  • design
  • DNA methylation
  • epigenetics
  • genomic location
  • methodological challenges
  • normalization
  • quality
  • standardization
  • PROMOTER METHYLATION
  • COLON-CANCER
  • GENE
  • GLIOMAS
  • PCR
  • CPG

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