Desphospho- uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population

O., Jr. Mayer; J. Seidlerova; P. Wohlfahrt; J. Filipovsky; J. Vanek; R. Cifkova; J. Windrichova; O. Topolcan; M. H. J. Knapen; N. E. A. Drummen; C. Vermeer

doi:10.1038/jhh.2015.55

Desphospho- uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population

O., Jr. Mayer^*, J. Seidlerova, P. Wohlfahrt, J. Filipovsky, J. Vanek, R. Cifkova, J. Windrichova, O. Topolcan, M. H. J. Knapen, N. E. A. Drummen, C. Vermeer

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Matrix Gla protein (MGP), a natural inhibitor of calcification, strongly correlates with the extent of coronary calcification. Vitamin K is the essential cofactor for the activation of MGP. The nonphosphorylated-uncarboxylated isoform of MGP (dp-ucMGP) reflects the status of this vitamin. We investigated whether there is an association between dp-ucMGP and stiffness of elastic and musculartype large arteries in a random sample from the general population. In a cross-sectional design, we analyzed 1087 subjects from the Czech post-MONICA study. Aortic and femoro-popliteal pulse wave velocities (PWVs) were measured using a Sphygmocor device. Dp-ucMGP concentrations were assessed in freshly frozen samples by enzyme-linked immunosorbent assay methods using the InaKtif MGP iSYS pre-commercial kit developed by IDS and VitaK. Aortic PWV significantly (P= 671 pmol l(-1)) had a higher risk of elevated aortic PWV, with corresponding adjusted odds ratio (95% confidence interval) 1.73 (1.17-2.5). In contrast, no relation between dp-ucMGP and femoro-popliteal PWV was found. In conclusion, increased dp-ucMGP, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries.

Original language	English
Pages (from-to)	418-423
Journal	Journal of Human Hypertension
Volume	30
Issue number	7
DOIs	https://doi.org/10.1038/jhh.2015.55
Publication status	Published - Jul 2016

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Mayer, O. . J., Seidlerova, J., Wohlfahrt, P., Filipovsky, J., Vanek, J., Cifkova, R., Windrichova, J., Topolcan, O., Knapen, M. H. J., Drummen, N. E. A., & Vermeer, C. (2016). Desphospho- uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population. Journal of Human Hypertension, 30(7), 418-423. https://doi.org/10.1038/jhh.2015.55

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title = "Desphospho- uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population",

abstract = "Matrix Gla protein (MGP), a natural inhibitor of calcification, strongly correlates with the extent of coronary calcification. Vitamin K is the essential cofactor for the activation of MGP. The nonphosphorylated-uncarboxylated isoform of MGP (dp-ucMGP) reflects the status of this vitamin. We investigated whether there is an association between dp-ucMGP and stiffness of elastic and musculartype large arteries in a random sample from the general population. In a cross-sectional design, we analyzed 1087 subjects from the Czech post-MONICA study. Aortic and femoro-popliteal pulse wave velocities (PWVs) were measured using a Sphygmocor device. Dp-ucMGP concentrations were assessed in freshly frozen samples by enzyme-linked immunosorbent assay methods using the InaKtif MGP iSYS pre-commercial kit developed by IDS and VitaK. Aortic PWV significantly (P= 671 pmol l(-1)) had a higher risk of elevated aortic PWV, with corresponding adjusted odds ratio (95% confidence interval) 1.73 (1.17-2.5). In contrast, no relation between dp-ucMGP and femoro-popliteal PWV was found. In conclusion, increased dp-ucMGP, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries.",

author = "Mayer, {O., Jr.} and J. Seidlerova and P. Wohlfahrt and J. Filipovsky and J. Vanek and R. Cifkova and J. Windrichova and O. Topolcan and Knapen, {M. H. J.} and Drummen, {N. E. A.} and C. Vermeer",

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AU - Mayer, O., Jr.

AU - Seidlerova, J.

AU - Wohlfahrt, P.

AU - Filipovsky, J.

AU - Vanek, J.

AU - Cifkova, R.

AU - Windrichova, J.

AU - Topolcan, O.

AU - Knapen, M. H. J.

AU - Drummen, N. E. A.

AU - Vermeer, C.

PY - 2016/7

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N2 - Matrix Gla protein (MGP), a natural inhibitor of calcification, strongly correlates with the extent of coronary calcification. Vitamin K is the essential cofactor for the activation of MGP. The nonphosphorylated-uncarboxylated isoform of MGP (dp-ucMGP) reflects the status of this vitamin. We investigated whether there is an association between dp-ucMGP and stiffness of elastic and musculartype large arteries in a random sample from the general population. In a cross-sectional design, we analyzed 1087 subjects from the Czech post-MONICA study. Aortic and femoro-popliteal pulse wave velocities (PWVs) were measured using a Sphygmocor device. Dp-ucMGP concentrations were assessed in freshly frozen samples by enzyme-linked immunosorbent assay methods using the InaKtif MGP iSYS pre-commercial kit developed by IDS and VitaK. Aortic PWV significantly (P= 671 pmol l(-1)) had a higher risk of elevated aortic PWV, with corresponding adjusted odds ratio (95% confidence interval) 1.73 (1.17-2.5). In contrast, no relation between dp-ucMGP and femoro-popliteal PWV was found. In conclusion, increased dp-ucMGP, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries.

AB - Matrix Gla protein (MGP), a natural inhibitor of calcification, strongly correlates with the extent of coronary calcification. Vitamin K is the essential cofactor for the activation of MGP. The nonphosphorylated-uncarboxylated isoform of MGP (dp-ucMGP) reflects the status of this vitamin. We investigated whether there is an association between dp-ucMGP and stiffness of elastic and musculartype large arteries in a random sample from the general population. In a cross-sectional design, we analyzed 1087 subjects from the Czech post-MONICA study. Aortic and femoro-popliteal pulse wave velocities (PWVs) were measured using a Sphygmocor device. Dp-ucMGP concentrations were assessed in freshly frozen samples by enzyme-linked immunosorbent assay methods using the InaKtif MGP iSYS pre-commercial kit developed by IDS and VitaK. Aortic PWV significantly (P= 671 pmol l(-1)) had a higher risk of elevated aortic PWV, with corresponding adjusted odds ratio (95% confidence interval) 1.73 (1.17-2.5). In contrast, no relation between dp-ucMGP and femoro-popliteal PWV was found. In conclusion, increased dp-ucMGP, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries.

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