Desphospho- uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population

O., Jr. Mayer*, J. Seidlerova, P. Wohlfahrt, J. Filipovsky, J. Vanek, R. Cifkova, J. Windrichova, O. Topolcan, M. H. J. Knapen, N. E. A. Drummen, C. Vermeer

*Corresponding author for this work

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Abstract

Matrix Gla protein (MGP), a natural inhibitor of calcification, strongly correlates with the extent of coronary calcification. Vitamin K is the essential cofactor for the activation of MGP. The nonphosphorylated-uncarboxylated isoform of MGP (dp-ucMGP) reflects the status of this vitamin. We investigated whether there is an association between dp-ucMGP and stiffness of elastic and musculartype large arteries in a random sample from the general population. In a cross-sectional design, we analyzed 1087 subjects from the Czech post-MONICA study. Aortic and femoro-popliteal pulse wave velocities (PWVs) were measured using a Sphygmocor device. Dp-ucMGP concentrations were assessed in freshly frozen samples by enzyme-linked immunosorbent assay methods using the InaKtif MGP iSYS pre-commercial kit developed by IDS and VitaK. Aortic PWV significantly (P= 671 pmol l(-1)) had a higher risk of elevated aortic PWV, with corresponding adjusted odds ratio (95% confidence interval) 1.73 (1.17-2.5). In contrast, no relation between dp-ucMGP and femoro-popliteal PWV was found. In conclusion, increased dp-ucMGP, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries.
Original languageEnglish
Pages (from-to)418-423
JournalJournal of Human Hypertension
Volume30
Issue number7
DOIs
Publication statusPublished - Jul 2016

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