Designing gradient plotted scaffolds as a tool for improving osteochondral regeneration

Andrea Di Luca

Research output: ThesisDoctoral ThesisExternal prepared

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Abstract

The osteochondral tissue has a gradient structure. In this research a 3D structures (called scaffolds) is developed, produced via 3D printing, presenting gradients in structural properties (porosity and pore shape), material properties (different materials in the same structure) and biological signals. The aim was to stimulate adult stem cells to become bone cells on one side of the construct and cartilage cells on the other side, simulating what happens in human joints. Scaffolds presenting a gradual variation in pore size and shape stimulated the adult stem cells to differentiate in the proper way, creating a structure similar to the osteochondral one in vitro. The importance of this research is the first step in development of a medical device for osteochondral treatment.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • van Blitterswijk, Clemens, Supervisor
  • Moroni, Lorenzo, Supervisor
Award date8 Jun 2017
Place of PublicationMaastricht
Publisher
Print ISBNs9789462336339
DOIs
Publication statusPublished - 2017

Keywords

  • joint regeneration
  • adult stem cells
  • 3D scaffolds
  • regenerative medicine

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