Design, synthesis, imaging, and biomechanics of a softness-gradient hydrogel nucleus pulposus prosthesis in a canine lumbar spine model

Hendrik-Jan C. Kranenburg, Bjorn P. Meij*, David Onis, Albert J. van der Veen, Ketie Saralidze, Luc A. Smolders, Julie G. Huizinga, Menno L. W. Knetsch, Peter R. Luijten, Fredy Visser, George Voorhout, Wouter J. A. Dhert, Herman A. W. Hazewinkel, Leo H. Koole

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)2148-2155
JournalJournal of Biomedical Materials Research Part B-applied Biomaterials
Issue number8
Publication statusPublished - Nov 2012


  • hydrogel
  • softness gradient
  • nucleus pulposus replacement
  • intervertebral disc
  • radiopacity

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