Design and rationale of ischaemia-driven complete revascularisation versus usual care in patients with non-ST-elevation myocardial infarction and multivessel coronary disease: the South Limburg Myocardial Infarction (SLIM) trial

T.F.S. Pustjens*, B. Streukens, J. Vainer, B. Gho, A.W. Ruiters, M. Stein, M. Ilhan, L. Veenstra, R. Theunissen, S.C.A.M. Bekkers, A.W.J. Van't Hof, S. Rasoul

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Aims To compare ischaemia-driven complete coronary revascularisation by percutaneous coronary intervention (PCI) with usual care in patients with non-ST-elevation myocardial infarction (non-STEMI) and multivessel disease (MVD). Methods The South Limburg Myocardial Infarction (SLIM) trial (NCT03562572) is an investigator-initiated, prospective, multicentre, randomised controlled trial that compares fractional flow reserve (FFR)-guided complete revascularisation during the index procedure with usual care in non-STEMI patients with MVD. A total of 414 patients will be randomised in a 1:1 fashion. The primary endpoint is the composite of all-cause mortality, non-fatal myocardial infarction, and any revascularisation and stroke (MACCE) at 12 months. The secondary endpoints are: MACCE at 24 and 36 months, and the composite of cardiac death, myocardial infarction, any revascularisation, stroke, major bleeding and left ventricular ejection fraction below 45% at 12, 24 and 36 months. Furthermore, quality of life will be assessed by the Patient Health Questionnaire (PHQ-9) and the Short Form (36) Health Survey (SF-36) at 1 and 12 months of follow-up. Conclusion The SLIM trial aims to provide evidence whether FFR-guided complete revascularisation by PCI is superior to usual care with respect to clinical outcomes (major adverse cardiovascular events) in non-STEMI patients with MVD.
Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalNetherlands Heart Journal
Volume28
Issue number2
DOIs
Publication statusPublished - 1 Feb 2020

Keywords

  • acute coronary syndrome
  • angiography
  • angioplasty
  • artery-disease
  • complete revascularisation
  • culprit-lesion
  • follow-up
  • fractional flow reserve
  • intervention
  • mortality
  • multivessel disease
  • non-st-elevation myocardial infarction
  • primary pci
  • unstable angina
  • MORTALITY
  • FOLLOW-UP
  • ANGIOPLASTY
  • Complete revascularisation
  • UNSTABLE ANGINA
  • INTERVENTION
  • FRACTIONAL FLOW RESERVE
  • Multivessel disease
  • PRIMARY PCI
  • ANGIOGRAPHY
  • Non-ST-elevation myocardial infarction
  • Acute coronary syndrome
  • CULPRIT-LESION
  • ARTERY-DISEASE

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