Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects

S.M. Reinartz; Joost van Tongeren; D. van Egmond; E.J. de Groot; W.J. Fokkens; C.M. van Drunen

doi:10.1371/journal.pone.0154409

Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects

S.M. Reinartz, Joost van Tongeren^*, D. van Egmond, E.J. de Groot, W.J. Fokkens, C.M. van Drunen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non-allergic individuals. Allergic individuals have more CD141+ myeloid cells in epithelium and more CD1a + Langerhans cells in the lamina propria compared to healthy controls, but similar numbers for the other DC subtypes. Our data are the first to describe the presence of CD303+ plasmacytoid DCs in human oral mucosa and a dense intraepithelial network of CD141+ DCs. The number of Langerhans type DCs (CD1a and CD207) and myeloid DCs (CD1c), was higher in the oral mucosa than in the nasal mucosa of the same individual independent of the atopic status.

Original language	English
Article number	e0154409
Number of pages	10
Journal	PLOS ONE
Volume	11
Issue number	5
DOIs	https://doi.org/10.1371/journal.pone.0154409
Publication status	Published - 11 May 2016

Keywords

T-CELLS
LANGERHANS CELLS
INHALED ANTIGEN
MAST-CELLS
NASAL
BLOOD
RATIO
SKIN
IMMUNOTHERAPY
INDUCTION

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Cite this

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title = "Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects",

abstract = "Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non-allergic individuals. Allergic individuals have more CD141+ myeloid cells in epithelium and more CD1a + Langerhans cells in the lamina propria compared to healthy controls, but similar numbers for the other DC subtypes. Our data are the first to describe the presence of CD303+ plasmacytoid DCs in human oral mucosa and a dense intraepithelial network of CD141+ DCs. The number of Langerhans type DCs (CD1a and CD207) and myeloid DCs (CD1c), was higher in the oral mucosa than in the nasal mucosa of the same individual independent of the atopic status.",

keywords = "T-CELLS, LANGERHANS CELLS, INHALED ANTIGEN, MAST-CELLS, NASAL, BLOOD, RATIO, SKIN, IMMUNOTHERAPY, INDUCTION",

author = "S.M. Reinartz and {van Tongeren}, Joost and {van Egmond}, D. and {de Groot}, E.J. and W.J. Fokkens and {van Drunen}, C.M.",

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AU - Reinartz, S.M.

AU - van Tongeren, Joost

AU - van Egmond, D.

AU - de Groot, E.J.

AU - Fokkens, W.J.

AU - van Drunen, C.M.

PY - 2016/5/11

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N2 - Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non-allergic individuals. Allergic individuals have more CD141+ myeloid cells in epithelium and more CD1a + Langerhans cells in the lamina propria compared to healthy controls, but similar numbers for the other DC subtypes. Our data are the first to describe the presence of CD303+ plasmacytoid DCs in human oral mucosa and a dense intraepithelial network of CD141+ DCs. The number of Langerhans type DCs (CD1a and CD207) and myeloid DCs (CD1c), was higher in the oral mucosa than in the nasal mucosa of the same individual independent of the atopic status.

AB - Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non-allergic individuals. Allergic individuals have more CD141+ myeloid cells in epithelium and more CD1a + Langerhans cells in the lamina propria compared to healthy controls, but similar numbers for the other DC subtypes. Our data are the first to describe the presence of CD303+ plasmacytoid DCs in human oral mucosa and a dense intraepithelial network of CD141+ DCs. The number of Langerhans type DCs (CD1a and CD207) and myeloid DCs (CD1c), was higher in the oral mucosa than in the nasal mucosa of the same individual independent of the atopic status.

KW - T-CELLS

KW - LANGERHANS CELLS

KW - INHALED ANTIGEN

KW - MAST-CELLS

KW - NASAL

KW - BLOOD

KW - RATIO

KW - SKIN

KW - IMMUNOTHERAPY

KW - INDUCTION

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