Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects

S.M. Reinartz, Joost van Tongeren, D. van Egmond, E.J. de Groot, W.J. Fokkens, C.M. van Drunen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non-allergic individuals. Allergic individuals have more CD141+ myeloid cells in epithelium and more CD1a + Langerhans cells in the lamina propria compared to healthy controls, but similar numbers for the other DC subtypes. Our data are the first to describe the presence of CD303+ plasmacytoid DCs in human oral mucosa and a dense intraepithelial network of CD141+ DCs. The number of Langerhans type DCs (CD1a and CD207) and myeloid DCs (CD1c), was higher in the oral mucosa than in the nasal mucosa of the same individual independent of the atopic status.

Original languageEnglish
Article numbere0154409
Number of pages10
JournalPLOS ONE
Volume11
Issue number5
DOIs
Publication statusPublished - 11 May 2016

Keywords

  • T-CELLS
  • LANGERHANS CELLS
  • INHALED ANTIGEN
  • MAST-CELLS
  • NASAL
  • BLOOD
  • RATIO
  • SKIN
  • IMMUNOTHERAPY
  • INDUCTION

Cite this

Reinartz, S. M., van Tongeren, J., van Egmond, D., de Groot, E. J., Fokkens, W. J., & van Drunen, C. M. (2016). Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects. PLOS ONE, 11(5), [e0154409]. https://doi.org/10.1371/journal.pone.0154409