Delivering therapeutics in peripheral artery disease: challenges and future perspectives

M.H. Vries, Mark Post

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Targeted and sustained delivery of biologicals to improve neovascularization has been focused on stimulation angiogenesis. The formation of collaterals however is hemodynamically much more efficient, but as a target of therapy has been under-utilized. Although there is good understanding of the molecular processes involving collateral formation and there are interesting drugable candidates, the need for targeting and sustained delivery is still an obstacle towards safe and effective treatment. Molecular targeting with nanoparticles of liposomes is promising and so are peri-vascularly delivered polymer-based protein reservoirs. These developments will lead to future arteriogenesis strategies that are adjunct to current revascularization.

Original languageEnglish
Pages (from-to)483-493
Number of pages11
JournalTherapeutic Delivery
Volume7
Issue number7
DOIs
Publication statusPublished - Jul 2016

Keywords

  • chemokine collateral formation
  • liposomes
  • neovascularization
  • polymer drug carriers
  • COLONY-STIMULATING FACTOR
  • ENDOTHELIAL GROWTH-FACTOR
  • CONTROLLED DRUG-DELIVERY
  • CRITICAL LIMB ISCHEMIA
  • BARE METAL STENTS
  • MYOCARDIAL-INFARCTION
  • COLLATERAL GROWTH
  • IN-VITRO
  • INTERMITTENT CLAUDICATION
  • MONOCYTE RECRUITMENT

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