TY - JOUR
T1 - Delaying memory decline
T2 - different options and emerging solutions
AU - Schneider, Felicitas
AU - Horowitz, Alan
AU - Lesch, Klaus-Peter
AU - Dandekar, Thomas
N1 - Funding Information:
The authors thank the Land of Bavaria for support. TD acknowledges funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Project number 3 74031971 – TRR 240/Z2. No commercially non-available materials (e.g., drugs) were used for this study.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/1/21
Y1 - 2020/1/21
N2 - Memory decline can be a devastating disease and increases in aging Western populations. Memory enhancement technologies hold promise for this and other conditions. Approaches include stem cell transplantation, which improved memory in several animal studies as well as vaccination against Alzheimer ' s disease (AD) by beta-amyloid antibodies. For a positive clinical effect, the vaccine should probably be administered over a long period of time and before amyloid pathologies manifest in the brain. Different drugs, such as erythropoietin or antiplatelet therapy, improve memory in neuropsychiatric diseases or AD or at least in animal studies. Omega-3 polyunsaturated fatty acid-rich diets improve memory through the gut-brain axis by altering the gut flora through probiotics. Sports, dancing, and memory techniques (e.g., Method of Loci) utilize behavioral approaches for memory enhancement, and were effective in several studies. Augmented reality (AR) is an auspicious way for enhancing memory in real time. Future approaches may include memory prosthesis for head-injured patients and light therapy for restoring memory in AD. Memory enhancement in humans in health and disease holds big promises for the future. Memory training helps only in mild or no impairment. Clinical application requires further investigation.
AB - Memory decline can be a devastating disease and increases in aging Western populations. Memory enhancement technologies hold promise for this and other conditions. Approaches include stem cell transplantation, which improved memory in several animal studies as well as vaccination against Alzheimer ' s disease (AD) by beta-amyloid antibodies. For a positive clinical effect, the vaccine should probably be administered over a long period of time and before amyloid pathologies manifest in the brain. Different drugs, such as erythropoietin or antiplatelet therapy, improve memory in neuropsychiatric diseases or AD or at least in animal studies. Omega-3 polyunsaturated fatty acid-rich diets improve memory through the gut-brain axis by altering the gut flora through probiotics. Sports, dancing, and memory techniques (e.g., Method of Loci) utilize behavioral approaches for memory enhancement, and were effective in several studies. Augmented reality (AR) is an auspicious way for enhancing memory in real time. Future approaches may include memory prosthesis for head-injured patients and light therapy for restoring memory in AD. Memory enhancement in humans in health and disease holds big promises for the future. Memory training helps only in mild or no impairment. Clinical application requires further investigation.
KW - RECOMBINANT-HUMAN-ERYTHROPOIETIN
KW - AMYLOID-BASED IMMUNOTHERAPY
KW - MILD COGNITIVE IMPAIRMENT
KW - AUGMENTED REALITY
KW - GUT MICROBIOTA
KW - ALZHEIMERS-DISEASE
KW - MIXED REALITY
KW - CELLS
KW - RATS
KW - RETRIEVAL
U2 - 10.1038/s41398-020-0697-x
DO - 10.1038/s41398-020-0697-x
M3 - Article
C2 - 32066684
SN - 2158-3188
VL - 10
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 13
ER -