Degradation elastischer Fasern in thorakoabdominellen Aortenaneurysmen: Ein multinationales und multizentrisches Forschungsprojekt mit Vorbildcharakter

C. Bassett; P. Doukas; A. Gombert; L. Schurgers; M. Jacobs; C. Uhl; B. Hruschka

doi:10.1007/s00772-025-01181-5

Degradation elastischer Fasern in thorakoabdominellen Aortenaneurysmen: Ein multinationales und multizentrisches Forschungsprojekt mit Vorbildcharakter

Translated title of the contribution: Degradation of elastic fibers in thoracoabdominal aortic aneurysms: A multinational and multicenter research project with examplary character

C. Bassett, P. Doukas, A. Gombert, L. Schurgers, M. Jacobs, C. Uhl, B. Hruschka^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

In the research of rare diseases, such as thoracoabdominal aortic aneurysms (TAAA), where obtaining tissue samples is challenging, research collaborations offer substantial advantages. In recent years, a comprehensive biobank for tissue, blood and urine samples from TAAA patients with and without genetic connective tissue disorders has been established in Aachen. To study changes in extracellular matrix components, particularly elastic fibers, our research group collaborates with various national and international partners, with the aim to promote the exchange of biomaterials, methodological competence and equipment.

Translated title of the contribution	Degradation of elastic fibers in thoracoabdominal aortic aneurysms: A multinational and multicenter research project with examplary character
Original language	German
Number of pages	4
Journal	Gefässchirurgie
DOIs	https://doi.org/10.1007/s00772-025-01181-5
Publication status	Published - 1 Jan 2025

Keywords

Biobank
Extrazellul & auml
re Matrixkomponenten
Desmosin
Forschungsnetzwerk
Grundlagenforschung
Extracellular matrix components
Desmosine
Research network
Basic research
TOTAL DESMOSINE
ISODESMOSINE

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title = "Degradation elastischer Fasern in thorakoabdominellen Aortenaneurysmen: Ein multinationales und multizentrisches Forschungsprojekt mit Vorbildcharakter",

abstract = "In the research of rare diseases, such as thoracoabdominal aortic aneurysms (TAAA), where obtaining tissue samples is challenging, research collaborations offer substantial advantages. In recent years, a comprehensive biobank for tissue, blood and urine samples from TAAA patients with and without genetic connective tissue disorders has been established in Aachen. To study changes in extracellular matrix components, particularly elastic fibers, our research group collaborates with various national and international partners, with the aim to promote the exchange of biomaterials, methodological competence and equipment.",

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T2 - Ein multinationales und multizentrisches Forschungsprojekt mit Vorbildcharakter

AU - Bassett, C.

AU - Doukas, P.

AU - Gombert, A.

AU - Schurgers, L.

AU - Jacobs, M.

AU - Uhl, C.

AU - Hruschka, B.

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KW - Desmosin

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KW - Grundlagenforschung

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KW - Desmosine

KW - Research network

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