Definitive radiation therapy for treatment of laryngeal carcinoma Impact of local relapse on outcome and implications for treatment strategies

F. Hoebers*, E. Rios, E. Troost, P. van den Ende, K. Kross, M. Lacko, R. Lalisang, B. Kremer, J. de Jong

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Purpose. The purpose of this work was to evaluate outcome after radiotherapy (RT) for laryngeal carcinoma and investigate effects of local relapse on ultimate disease control, including surgical salvage procedures. Methods and materials. In all, 435 patients with laryngeal carcinoma (cT1-cT4a) treated with primary RT were retrospectively analyzed. Uni- and multivariate analyses were performed to identify prognostic factors for local relapse-free survival and overall survival. Results. Median follow-up was 38 months (range 1-144 months). The cumulative frequency of local recurrence was dependent on T stage: cT1 tumors 10%, cT2 18%, cT3 23%, and cT4 36% (p
Original languageEnglish
Pages (from-to)834-841
JournalStrahlentherapie Und onkologie
Issue number10
Publication statusPublished - Oct 2013


  • Laryngeal carcinoma
  • Radiotherapy
  • Chemoradiation
  • Surgery
  • Laryngectomy

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