Defining oligometastatic non-small cell lung cancer: A simulated multidisciplinary expert opinion

Lizza E. L. Hendriks*, Christophe Dooms, Thierry Berghmans, Silvia Novello, Antonin Levy, Dirk De Ruysscher, Baktiar Hasan, Matteo Giaj Levra, Niccolo Giaj Levra, Benjamin Besse, Johan Vansteenkiste, Anne-Marie C. Dingemans, European Organisation for Research and Treatment of Cancer (EORTC) Lung Cancer Group

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Introduction: Synchronous oligometastatic non-small cell lung cancer (NSCLC) definition varies from 1 metastasis in 1 organ (tumour-node-metastasis 8 [TNM8]), 1-3 metastases (European Society for Medical Oncology [ESMO]),

Methods: In December 2017, 10 real-life multidisciplinary team (MDT) discussed patients (good condition, no significant comorbidities, F-18-fluorodeoxyglucose positron emission tomography/brain magnetic resonance imaging staged, all <5 metastases, 9/10

Results: Twenty-six of 33 experts (24 centres) replied: 8 medical oncologists, 7 pulmonologists, 7 radiation oncologists, 4 thoracic surgeons. Sixty-two percent of respondents discussed the cases with their MDT. One case had 100% oligometastatic consensus, and 3 cases had >90% consensus; the number of treatment proposals varied between 3 and 8. Radical treatment was more often offered in case of single metastasis or N0. Compared with 2012, there was a trend towards a more conservative oligometastatic definition and chemotherapy was more frequently included in the treatment proposal.

Conclusions: Oligometastatic NSCLC definition was conservative. The number of organs, MLN status and radical treatment possibility seem to be components of daily practice oligometastatic definition. (C) 2019 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)28-35
Number of pages8
JournalEuropean Journal of Cancer
Volume123
DOIs
Publication statusPublished - Dec 2019

Keywords

  • NSCLC
  • Oligometastatic
  • Definition
  • Case-based survey
  • NSCLC FOLLOWING COMPLETION
  • TNM STAGE GROUPINGS
  • PHASE-II
  • ADRENAL METASTASES
  • RADIATION-THERAPY
  • RADICAL TREATMENT
  • PROGNOSTIC VALUE
  • OUTCOMES
  • PROJECT
  • CLASSIFICATION

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