Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8(+) T cell-mediated macrophage death

Tom T. P. Seijkens, Kikkie Poels, Svenja Meiler, Claudia M. van Tiel, Pascal J. H. Kusters, Myrthe Reiche, Dorothee Atzler, Holger Winkels, Marc Tjwa, Hessel Poelman, Bram Slutter, Johan Kuiper, Marion Gijbels, Jan Albert Kuivenhoven, Ljubica Perisic Matic, Gabrielle Paulsson-Berne, Ulf Hedin, Goran K. Hansson, Gerry A. F. Nicolaes, Mat J. A. P. DaemenChristian Weber, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)372-382
Number of pages12
JournalEuropean Heart Journal
Volume40
Issue number4
DOIs
Publication statusPublished - 21 Jan 2019

Keywords

  • Atherosclerosis
  • Innate and adaptive immune system
  • Macrophages
  • T cells
  • CBL-B
  • E3 UBIQUITIN LIGASE
  • GENE
  • LYMPHOCYTES

Cite this

Seijkens, T. T. P., Poels, K., Meiler, S., van Tiel, C. M., Kusters, P. J. H., Reiche, M., Atzler, D., Winkels, H., Tjwa, M., Poelman, H., Slutter, B., Kuiper, J., Gijbels, M., Kuivenhoven, J. A., Matic, L. P., Paulsson-Berne, G., Hedin, U., Hansson, G. K., Nicolaes, G. A. F., ... Lutgens, E. (2019). Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8(+) T cell-mediated macrophage death. European Heart Journal, 40(4), 372-382. https://doi.org/10.1093/eurheartj/ehy714