Deep brain stimulation of the nucleus accumbens core and shell: Opposite effects on impulsive action

T.J.J. Sesia, Y. Temel, L.W. Lim, A. Blokland, H.P. Steinbusch, V.E.R.M. Visser-Vandewalle

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

Abstract

The nucleus accumbens is gaining interest as a target for deep brain stimulation in refractory neuropsychiatric disorders with impulsivity as core symptom. The nucleus accumbens is composed of two subterritories, core and shell, which have different anatomical connections. Here, we tested the hypothesis that stimulation of the nucleus accumbens core and shell would have different effects on impulsivity, Rats received bilateral Stimulation at the level of the nucleus accumbens Core or shell during a reaction time task. Stimulation of the nucleus accumbens core significantly decreased impulsivity, while stimulation of the shell increased it. our results support the hypothesis that the nucleus accumbens is a potential target to treat neuropsychiatric disorders related to impulsivity by deep brain Stimulation. However, different behavioral effects resulting from stimulation of the subterritories should be taken into account. Crown
Original languageEnglish
Pages (from-to)135-139
JournalExperimental Neurology
Volume214
Issue number1
DOIs
Publication statusPublished - 1 Jan 2008

Cite this

@article{3cea7d6e1f4945c9b8d7fa45fde02426,
title = "Deep brain stimulation of the nucleus accumbens core and shell: Opposite effects on impulsive action",
abstract = "The nucleus accumbens is gaining interest as a target for deep brain stimulation in refractory neuropsychiatric disorders with impulsivity as core symptom. The nucleus accumbens is composed of two subterritories, core and shell, which have different anatomical connections. Here, we tested the hypothesis that stimulation of the nucleus accumbens core and shell would have different effects on impulsivity, Rats received bilateral Stimulation at the level of the nucleus accumbens Core or shell during a reaction time task. Stimulation of the nucleus accumbens core significantly decreased impulsivity, while stimulation of the shell increased it. our results support the hypothesis that the nucleus accumbens is a potential target to treat neuropsychiatric disorders related to impulsivity by deep brain Stimulation. However, different behavioral effects resulting from stimulation of the subterritories should be taken into account. Crown",
author = "T.J.J. Sesia and Y. Temel and L.W. Lim and A. Blokland and H.P. Steinbusch and V.E.R.M. Visser-Vandewalle",
year = "2008",
month = "1",
day = "1",
doi = "10.1016/j.expneurol.2008.07.015",
language = "English",
volume = "214",
pages = "135--139",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Elsevier Science",
number = "1",

}

Deep brain stimulation of the nucleus accumbens core and shell: Opposite effects on impulsive action. / Sesia, T.J.J.; Temel, Y.; Lim, L.W.; Blokland, A.; Steinbusch, H.P.; Visser-Vandewalle, V.E.R.M.

In: Experimental Neurology, Vol. 214, No. 1, 01.01.2008, p. 135-139.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Deep brain stimulation of the nucleus accumbens core and shell: Opposite effects on impulsive action

AU - Sesia, T.J.J.

AU - Temel, Y.

AU - Lim, L.W.

AU - Blokland, A.

AU - Steinbusch, H.P.

AU - Visser-Vandewalle, V.E.R.M.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - The nucleus accumbens is gaining interest as a target for deep brain stimulation in refractory neuropsychiatric disorders with impulsivity as core symptom. The nucleus accumbens is composed of two subterritories, core and shell, which have different anatomical connections. Here, we tested the hypothesis that stimulation of the nucleus accumbens core and shell would have different effects on impulsivity, Rats received bilateral Stimulation at the level of the nucleus accumbens Core or shell during a reaction time task. Stimulation of the nucleus accumbens core significantly decreased impulsivity, while stimulation of the shell increased it. our results support the hypothesis that the nucleus accumbens is a potential target to treat neuropsychiatric disorders related to impulsivity by deep brain Stimulation. However, different behavioral effects resulting from stimulation of the subterritories should be taken into account. Crown

AB - The nucleus accumbens is gaining interest as a target for deep brain stimulation in refractory neuropsychiatric disorders with impulsivity as core symptom. The nucleus accumbens is composed of two subterritories, core and shell, which have different anatomical connections. Here, we tested the hypothesis that stimulation of the nucleus accumbens core and shell would have different effects on impulsivity, Rats received bilateral Stimulation at the level of the nucleus accumbens Core or shell during a reaction time task. Stimulation of the nucleus accumbens core significantly decreased impulsivity, while stimulation of the shell increased it. our results support the hypothesis that the nucleus accumbens is a potential target to treat neuropsychiatric disorders related to impulsivity by deep brain Stimulation. However, different behavioral effects resulting from stimulation of the subterritories should be taken into account. Crown

U2 - 10.1016/j.expneurol.2008.07.015

DO - 10.1016/j.expneurol.2008.07.015

M3 - Article

VL - 214

SP - 135

EP - 139

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 1

ER -