Deep Brain Stimulation of the internal globus pallidus in refractory Tourette Syndrome

A. Y. J. M. Smeets*, A. A. Duits, B. R. Plantinga, A. F. G. Leentjens, M. Oosterloo, V. Visser-Vandewalle, Y. Temel, L. Ackermans

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Web of Science)

Abstract

Objective: Deep Brain Stimulation in psychiatric disorders is becoming an increasingly performed surgery. At present, seven different targets have been stimulated in Tourette Syndrome, including the internal globus pallidus. We describe the effects on tics and comorbid behavioral disorders of Deep Brain Stimulation of the anterior internal globus pallidus in five patients with refractory Tourette Syndrome. Methods: This study was performed as an open label study with follow-up assessment between 12 and 38 months. Patients were evaluated twice, one month before surgery and at long-term follow-up. Primary outcome was tic severity, assessed by several scales. Secondary outcomes were comorbid behavioral disorders, mood and cognition. The final position of the active contacts of the implanted electrodes was investigated and side effects were reported. Results: Three males and two females were included with a mean age of 41.6 years (SD 9.7). The total post-operative score on the Yale Global Tic Severity Scale was significantly lower than the pre-operative score (42.2 +/- 4.8 versus 12.8 +/- 3.8, P=0.043). There was also a significant reduction on the modified Rush Video-Based Tic Rating Scale (13.0 +/- 2.0 versus 7.0 +/- 1.6, P=0.041) and in the total number of video-rated tics (259.6 +/- 107.3 versus 49.6 +/- 24.8, P=0.043). No significant difference on the secondary outcomes was found, however, there was an improvement on an individual level for obsessive-compulsive behavior. The final position of the active contacts was variable in our sample and no relationship between position and stimulation effects could be established. Conclusion: Our study suggests that Deep Brain Stimulation of the anterior internal globus pallidus is effective in reducing tic severity, and possibly also obsessive-compulsive behavior, in refractory Tourette patients without serious adverse events or side-effects.
Original languageEnglish
Pages (from-to)54-59
JournalClinical Neurology and Neurosurgery
Volume142
DOIs
Publication statusPublished - Mar 2016

Keywords

  • Tourette Syndrome
  • Refractory
  • Deep Brain Stimulation
  • Internal globus pallidus
  • Tic reduction
  • Obsessive-compulsive behavior

Cite this