TY - JOUR
T1 - Deep Brain Stimulation for Psychiatric Disease: Contributions and Validity of Animal Models
AU - Hamani, Clement
AU - Temel, Yasin
PY - 2012/7/11
Y1 - 2012/7/11
N2 - During treatment with deep brain stimulation (DBS), electrical current is delivered into the brain parenchyma through implanted electrodes. Although this technique is routinely used in the treatment of Parkinson's disease, essential tremor, and dystonia, a growing number of neuropsychiatric applications for DBS are being investigated. Investigators can use animal models of these diseases to study the mechanisms through which DBS exerts its effects, to explore new applications of this therapy, and to identify and characterize alternative stimulation targets. Here, we discuss preclinical DBS research that provides insight into the mechanisms underlying cognitive and psychiatric applications of this technique, emphasizing the predictive validity of animal models and their potential use in translational research.
AB - During treatment with deep brain stimulation (DBS), electrical current is delivered into the brain parenchyma through implanted electrodes. Although this technique is routinely used in the treatment of Parkinson's disease, essential tremor, and dystonia, a growing number of neuropsychiatric applications for DBS are being investigated. Investigators can use animal models of these diseases to study the mechanisms through which DBS exerts its effects, to explore new applications of this therapy, and to identify and characterize alternative stimulation targets. Here, we discuss preclinical DBS research that provides insight into the mechanisms underlying cognitive and psychiatric applications of this technique, emphasizing the predictive validity of animal models and their potential use in translational research.
U2 - 10.1126/scitranslmed.3003722
DO - 10.1126/scitranslmed.3003722
M3 - Article
C2 - 22786683
SN - 1946-6234
VL - 4
JO - Science Translational Medicine
JF - Science Translational Medicine
IS - 142
M1 - 142rv8
ER -