Deep brain stimulation and cognition: Translational aspects

Sarah Hescham*, Huajie Liu, Ali Jahanshahi, Yasin Temel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Web of Science)

Abstract

Many neurological patients suffer from memory loss. To date, pharmacological treatments for memory disorders have limited and short-lasting effects. Therefore, researchers are investigating novel therapies such as deep brain stimulation (DBS) to alleviate memory impairments. Up to now stimulation of the fornix, nucleus basalis of Meynert and entorhinal cortex have been found to enhance memory performance. Here, we provide an overview of the different DBS targets and mechanisms within the memory circuit, which could be relevant for enhancing memory in patients. Future studies are warranted, accelerating the efforts to further unravel mechanisms of action of DBS in memory-related disorders and develop stimulation protocols based on these mechanisms.

Original languageEnglish
Article number107283
Number of pages10
JournalNeurobiology of Learning and Memory
Volume174
DOIs
Publication statusPublished - Oct 2020

Keywords

  • ANTERIOR THALAMIC NUCLEI
  • Alzheimer disease
  • Deep brain stimulation
  • ELECTRICAL-STIMULATION
  • Fornix
  • HIGH-FREQUENCY STIMULATION
  • MEMORY ENHANCEMENT
  • Mechanisms
  • NIGRA PARS RETICULATA
  • Nucleus basalis of Meynert
  • PARKINSONS-DISEASE
  • PROPOSED MECHANISM
  • SPATIAL MEMORY
  • SUBSTANTIA-NIGRA
  • SUBTHALAMIC STIMULATION
  • MEYNERT

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