Decreased energy and phosphorylation status in the liver of lung cancer patients with eight loss

S. Leij-Halfwerk, P.C. Dagnelie*, P. Kappert, M. Oudkerk, P.E. Sijens

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Web of Science)


Background/Aims: Altered energy status has been reported in the liver of tumour-bearing animals, but data on energy status in humans are scarce. Therefore, bioenergetics in tumour-free liver of lung cancer patients were monitored using P-31 magnetic resonance spectroscopy (MRS) with infusion of L-alanine as a gluconeogenic challenge. Methods: Twenty-one overnight-fasted lung cancer patients without liver metastases, with (CaWL) or without weight loss (CaWS), and 12 healthy control subjects (C) were studied. Hepatic energy status was monitored before and during an i.v. L-alanine infusion of 1.4-2.8 mmol/kg + 2.8 mmol . kg(-1). h(-1) for 90 min by P-31 MR spectroscopy. Results: Baseline levels of ATP in WL lung cancer patients, expressed relative to total MR-detectable phosphate, were reduced (CaWL, 9.5+/-0.9% vs. CaWS, 12.6+/-0.8% and C, 12.4+/-0.8%; p
Original languageEnglish
Pages (from-to)887-892
Number of pages6
JournalJournal of Hepatology
Publication statusPublished - 1 Jan 2000

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