TY - JOUR
T1 - Decreased energy and phosphorylation status in the liver of lung cancer patients with eight loss
AU - Leij-Halfwerk, S.
AU - Dagnelie, P.C.
AU - Kappert, P.
AU - Oudkerk, M.
AU - Sijens, P.E.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Background/Aims: Altered energy status has been reported in the liver of tumour-bearing animals, but data on energy status in humans are scarce. Therefore, bioenergetics in tumour-free liver of lung cancer patients were monitored using P-31 magnetic resonance spectroscopy (MRS) with infusion of L-alanine as a gluconeogenic challenge. Methods: Twenty-one overnight-fasted lung cancer patients without liver metastases, with (CaWL) or without weight loss (CaWS), and 12 healthy control subjects (C) were studied. Hepatic energy status was monitored before and during an i.v. L-alanine infusion of 1.4-2.8 mmol/kg + 2.8 mmol . kg(-1). h(-1) for 90 min by P-31 MR spectroscopy. Results: Baseline levels of ATP in WL lung cancer patients, expressed relative to total MR-detectable phosphate, were reduced (CaWL, 9.5+/-0.9% vs. CaWS, 12.6+/-0.8% and C, 12.4+/-0.8%; p
AB - Background/Aims: Altered energy status has been reported in the liver of tumour-bearing animals, but data on energy status in humans are scarce. Therefore, bioenergetics in tumour-free liver of lung cancer patients were monitored using P-31 magnetic resonance spectroscopy (MRS) with infusion of L-alanine as a gluconeogenic challenge. Methods: Twenty-one overnight-fasted lung cancer patients without liver metastases, with (CaWL) or without weight loss (CaWS), and 12 healthy control subjects (C) were studied. Hepatic energy status was monitored before and during an i.v. L-alanine infusion of 1.4-2.8 mmol/kg + 2.8 mmol . kg(-1). h(-1) for 90 min by P-31 MR spectroscopy. Results: Baseline levels of ATP in WL lung cancer patients, expressed relative to total MR-detectable phosphate, were reduced (CaWL, 9.5+/-0.9% vs. CaWS, 12.6+/-0.8% and C, 12.4+/-0.8%; p
U2 - 10.1016/S0168-8278(00)80092-6
DO - 10.1016/S0168-8278(00)80092-6
M3 - Article
SN - 0168-8278
VL - 32
SP - 887
EP - 892
JO - Journal of Hepatology
JF - Journal of Hepatology
ER -