@article{fc777af62afe46188a8f226cb3cc35f5,
title = "Decoding the role of zebrafish neuroglia in CNS disease modeling",
abstract = "Neuroglia, including microglia and astrocytes, is a critical component of the central nervous system (CNS) that interacts with neurons to modulate brain activity, development, metabolism and signaling pathways. Thus, a better understanding of the role of neuroglia in the brain is critical. Complementing clinical and rodent data, the zebrafish (Danio rerio) is rapidly becoming an important model organism to probe the role of neuroglia in brain disorders. With high genetic and physiological similarity to humans and rodents, zebrafish possess some common (shared), as well as some specific molecular biomarkers and features of neuroglia development and functioning. Studying these common and zebrafish-specific aspects of neuroglia may generate important insights into key brain mechanisms, including neurodevelopmental, neurodegenerative, neuroregenerative and neurological processes. Here, we discuss the biology of neuroglia in humans, rodents and fish, its role in various CNS functions, and further directions of translational research into the role of neuroglia in CNS disorders using zebrafish models.",
keywords = "adult zebrafish, blood-brain-barrier, cns disorders, danio-rerio, growth-factor, in-vivo, macroglia, microglia, neural progenitors, neuroglia, radial glial-cells, rodents, scar formation, spinal-cord regeneration, zebrafish, NEURAL PROGENITORS, DANIO-RERIO, Neuroglia, MICROGLIA, Rodents, SCAR FORMATION, RADIAL GLIAL-CELLS, SPINAL-CORD REGENERATION, Zebrafish, Macroglia, ADULT ZEBRAFISH, BLOOD-BRAIN-BARRIER, Microglia, IN-VIVO, CNS disorders, GROWTH-FACTOR",
author = "K.N. Zabegalov and D.M. Wang and L.E. Yang and J.T. Wang and G.J. Hu and N. Serikuly and E.T. Alpyshov and S.L. Khatsko and A. Zhdanov and K.A. Demin and D.S. Galstyan and A.D. Volgin and {de Abreu}, M.S. and T. Strekalova and C. Song and T.G. Amstislavskaya and Y. Sysoev and P.E. Musienko and A.V. Kalueff",
note = "Funding Information: AVK laboratory and this study are supported by the Southwest University (SWU, Chongqing, China) . KNZ exchange visit to SWU during this study was supported by Ural Federal University (Ekaterinburg, Russia). AVK is the President of the International Stress and Behavior Society (ISBS, www.stress-and-behavior.com ) and the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) that coordinated this multi-laboratory collaborative project. KAD is supported by the President of Russia{\textquoteright}s graduate fellowship, the St. Petersburg State University Rector{\textquoteright}s Special Productivity Fellowship for PhD students, and St. Petersburg State University grant for project ID: 51130521 . ADV is acknowledged for the protection of Siberia. This research and TGA's laboratory are supported by the Russian Science Foundation (RSF) grant grant 20-65-46006. DSG is supported by the RSF grant 19-15-00053. PEM and YuS are supported by the St. Petersburg State University grant for project 51134206. The funders had no role in the design, analyses and interpretation of the submitted study, or decision to publish. Funding Information: AVK laboratory and this study are supported by the Southwest University (SWU, Chongqing, China). KNZ exchange visit to SWU during this study was supported by Ural Federal University (Ekaterinburg, Russia). AVK is the President of the International Stress and Behavior Society (ISBS, www.stress-and-behavior.com) and the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) that coordinated this multi-laboratory collaborative project. KAD is supported by the President of Russia's graduate fellowship, the St. Petersburg State University Rector's Special Productivity Fellowship for PhD students, and St. Petersburg State University grant for project ID: 51130521. ADV is acknowledged for the protection of Siberia. This research and TGA's laboratory are supported by the Russian Science Foundation (RSF) grant grant 20-65-46006. DSG is supported by the RSF grant 19-15-00053. PEM and YuS are supported by the St. Petersburg State University grant for project 51134206. The funders had no role in the design, analyses and interpretation of the submitted study, or decision to publish. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = jan,
day = "1",
doi = "10.1016/j.brainresbull.2020.09.020",
language = "English",
volume = "166",
pages = "44--53",
journal = "Brain Research Bulletin",
issn = "0361-9230",
publisher = "Elsevier Inc.",
}