De rol van slaap bij ADHD: Mogelijkheden voor preventie van ADHD?

Background: Personalized medicine aims to provide the right treatment for the right person at the right time, as opposed to the currently employed 'one-size-fits-all' approach. This developmentrelies on identification of ADHD subgroups using biomarkers. One important ADHD subgroup is characterised by impaired vigilance regulation, as quantified by the eeg and this subgroup responds well to stimulant medication and neurofeedback. Recent insights suggest a clear association between reduced sleep duration and adhd complaints in this sub-group of adhd patients. A recently published model explains how different treatments e.g. chronobiological treatments and neurofeedback impact on this neural circuitry and mediate adhd symptom improvement. Aim: To test this recently published model predicting a relationship between solar intensity and adhd prevalence. Method: A literature survey onstudies using identical methods to estimate the prevalence of adhd in differentgeographical areas and compare those to worldwide solar intensity data. Results: A clear relationship between solar intensity and the worldwide prevalence of ADH D was found, explaining 34-57% of the variance in adhd prevalence, where a lower prevalence of adhd was found in areas with high solar-intensity. Conclusion: The preventative eject of high solar intensity may be related to improvement of circadian clock disturbances. These findings likely apply to a substantial sub-group of A DHD patients and have major implications for our understanding of the etiology and possibly prevention Of adhd.