De invasieve behandeling van diepveneuze trombose ter voorkoming van post-trombotisch syndroom

Deep venous thrombosis (DVT) is a frequently occurring disease in the western world. Despite optimal standard treatment, many patients develop post throm-botic syndrome (PTS). Especially the patients with an iliofemoral DVT have a high risk of developing PTS. In order to reduce the incidence of PTS after iliofemoral DVT Catheter Directed Thrombolysis (CDT) is used to dissolve the thrombus in the acute stage and thus preventing valve damage and vein obstruction and therefore hopefully decreasing the risk of PTS. The randomised Norwegian CaVenT-study reported in the beginning of 2012 an absolute risk reduction of 14, 4% in the group of patients additionally treated with CDT. There are currently two more randomised trials looking at prevention of PTS with CDT. New CDT devises are available which will hopefully result in thrombolysis. In the future we expect thrombolysis catheters with a purely mechanical function, thus lowering risk and making more patients eligible for acute thrombus removal.