Dapsone hypersensitivity syndrome not related to G6PD deficiency

K.J. Schulkes; Jan Cohen Tervaert; F. Rijken; L.E.  Haas

doi:10.1136/BCR-2015-212742

Dapsone hypersensitivity syndrome not related to G6PD deficiency

K.J. Schulkes, Jan Cohen Tervaert, F. Rijken, L.E. Haas^*

^*Corresponding author for this work

Faculteit FHML Centraal

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. We describe a 55-year-old Caucasian woman with normal glucose-6-phosphate dehydrogenase levels presenting with an extensive skin eruption, high-grade fever, pneumonitis and hepatitis, which occurred within 3 weeks after initiation of dapsone. In addition to supportive care, the patient was successfully treated with high-dose corticosteroids and antibiotics. The combination of high-grade fever, skin rash, lung and liver involvement made a dapsone hypersensitivity syndrome very likely.2015 BMJ Publishing Group Ltd.

Original language	English
Article number	bcr2015212742
Journal	BMJ case Reports
DOIs	https://doi.org/10.1136/BCR-2015-212742
Publication status	Published - 2015

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title = "Dapsone hypersensitivity syndrome not related to G6PD deficiency",

abstract = "Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. We describe a 55-year-old Caucasian woman with normal glucose-6-phosphate dehydrogenase levels presenting with an extensive skin eruption, high-grade fever, pneumonitis and hepatitis, which occurred within 3 weeks after initiation of dapsone. In addition to supportive care, the patient was successfully treated with high-dose corticosteroids and antibiotics. The combination of high-grade fever, skin rash, lung and liver involvement made a dapsone hypersensitivity syndrome very likely.2015 BMJ Publishing Group Ltd.",

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AU - Cohen Tervaert, Jan

AU - Rijken, F.

AU - Haas, L.E.

PY - 2015

Y1 - 2015

N2 - Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. We describe a 55-year-old Caucasian woman with normal glucose-6-phosphate dehydrogenase levels presenting with an extensive skin eruption, high-grade fever, pneumonitis and hepatitis, which occurred within 3 weeks after initiation of dapsone. In addition to supportive care, the patient was successfully treated with high-dose corticosteroids and antibiotics. The combination of high-grade fever, skin rash, lung and liver involvement made a dapsone hypersensitivity syndrome very likely.2015 BMJ Publishing Group Ltd.

AB - Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. We describe a 55-year-old Caucasian woman with normal glucose-6-phosphate dehydrogenase levels presenting with an extensive skin eruption, high-grade fever, pneumonitis and hepatitis, which occurred within 3 weeks after initiation of dapsone. In addition to supportive care, the patient was successfully treated with high-dose corticosteroids and antibiotics. The combination of high-grade fever, skin rash, lung and liver involvement made a dapsone hypersensitivity syndrome very likely.2015 BMJ Publishing Group Ltd.

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DO - 10.1136/BCR-2015-212742

M3 - Article

SN - 1757-790X

JO - BMJ case Reports

JF - BMJ case Reports

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Dapsone hypersensitivity syndrome not related to G6PD deficiency

Abstract

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