Dapsone hypersensitivity syndrome not related to G6PD deficiency

K.J. Schulkes, Jan Cohen Tervaert, F. Rijken, L.E. Haas

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Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. We describe a 55-year-old Caucasian woman with normal glucose-6-phosphate dehydrogenase levels presenting with an extensive skin eruption, high-grade fever, pneumonitis and hepatitis, which occurred within 3 weeks after initiation of dapsone. In addition to supportive care, the patient was successfully treated with high-dose corticosteroids and antibiotics. The combination of high-grade fever, skin rash, lung and liver involvement made a dapsone hypersensitivity syndrome very likely.2015 BMJ Publishing Group Ltd.
Original languageEnglish
Article numberbcr2015212742
JournalBMJ case Reports
Publication statusPublished - 2015

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