Daily self-assessment within a regimen of microdosing indicates enhanced psychological functioning on microdosing days relative to non-microdosing days

Rationale: Repeated self-administration of small doses of psychedelics, known as microdosing, has been associated with perceived improvements in psychological functioning. However, few studies have examined effects at the daily level. Objectives: Drawing on data from a naturalistic, prospective, international survey of adults who microdose (N = 1435), we assessed self-reported within-person changes between microdosing days and non-microdosing days across six domains of psychological functioning. Results: Using multi-level modeling, we identified higher (p <.001) ratings of Wellbeing (F(1,768) = 160.15), Productivity (F(1,917) = 108.69), Creativity (F(1,899) = 25.99), Connectedness (F(1,859) = 253.4), Contemplation (F(1,864) = 180.5), and Focus (F(1,846) = 191.72) on microdosing days compared to non-microdosing days. For the domain of Creativity, increased scores were more pronounced among respondents with a history of using larger doses of psychedelics (F(1,899) = 4.40, p =.04). Conclusions: Given the observational and exploratory nature of this study, these findings should be interpreted with caution; nonetheless, the prospective data provides valuable real-time insights while reducing recall bias.