Daily energy expenditure through the human life course

H. Pontzer*, Y. Yamada*, H. Sagayama*, P.N. Ainslie, L.F. Andersen, L.J. Anderson, L. Arab, I. Baddou, K. Bedu-Addo, E.E. Blaak, S. Blanc, A.G. Bonomi, C.V.C. Bouten, P. Bovet, M.S. Buchowski, N.F. Butte, S.G. Camps, G.L. Close, J.A. Cooper, R. CooperS.K. Das, L.R. Dugas, U. Ekelund, S. Entringer, T. Forrester, B.W. Fudge, A.H. Goris, M. Gurven, C. Hambly, A. El Hamdouchi, M.B. Hoos, S.M. Hu, N. Joonas, A.M. Joosen, P. Katzmarzyk, K.P. Kempen, M. Kimura, W.E. Kraus, R.F. Kushner, E.V. Lambert, W.R. Leonard, N. Lessan, C. Martin, A.C. Medin, E.P. Meijer, J.C. Morehen, J.P. Morton, M.L. Neuhouser, T.A. Nicklas, R.M. Ojiambo, Guy Plasqui, Klaas Westerterp, IAEA DLW Database Consortium, Edgar A. van Mil

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

63 Citations (Web of Science)

Abstract

Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to similar to 50% above adult values at similar to 1 year; declines slowly to adult levels by similar to 20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.
Original languageEnglish
Pages (from-to)808-812
Number of pages34
JournalScience
Volume373
Issue number6556
DOIs
Publication statusPublished - 13 Aug 2021

Keywords

  • CELLULAR-LEVEL APPROACH
  • BASAL METABOLIC-RATE
  • PHYSICAL-ACTIVITY
  • LONGITUDINAL ASSESSMENT
  • SLEEP DURATION
  • ORGAN SIZE
  • WATER
  • CHILDREN
  • REQUIREMENTS
  • DEPOSITION

Cite this