Association of Prediabetes and Type 2 Diabetes With Cognitive Function After Stroke: A STROKOG Collaboration Study

Jessica W. Lo; John D. Crawford; Katherine Samaras; David W. Desmond; Sebastian Kohler; Julie Staals; Frans R. J. Verhey; Hee-Joon Bae; Keon-Joo Lee; Beom Joon Kim; Regis Bordet; Charlotte Cordonnier; Thibaut Dondaine; Anne-Marie Mendyk; Byung-Chul Lee; Kyung-Ho Yu; Jae-Sung Lim; Nagaendran Kandiah; Russell J. Chander; Chathuri Yatawara; Darren M. Lipnicki; Perminder S. Sachdev; STROKOG Collaboration

doi:10.1161/strokeaha.119.028428

Association of Prediabetes and Type 2 Diabetes With Cognitive Function After Stroke: A STROKOG Collaboration Study

Jessica W. Lo^*, John D. Crawford, Katherine Samaras, David W. Desmond, Sebastian Kohler, Julie Staals, Frans R. J. Verhey, Hee-Joon Bae, Keon-Joo Lee, Beom Joon Kim, Regis Bordet, Charlotte Cordonnier, Thibaut Dondaine, Anne-Marie Mendyk, Byung-Chul Lee, Kyung-Ho Yu, Jae-Sung Lim, Nagaendran Kandiah, Russell J. Chander, Chathuri YatawaraDarren M. Lipnicki, Perminder S. Sachdev, STROKOG Collaboration

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background and Purpose-

Type 2 diabetes mellitus (T2D) is associated with cognitive impairment and an increased risk of dementia, but the association between prediabetes and cognitive impairment is less clear, particularly in a setting of major cerebrovascular events. This article examines the impact of impaired fasting glucose and T2D on cognitive performance in a stroke population.

Methods-

Seven international observational studies from the STROKOG (Stroke and Cognition) consortium (n=1601; mean age, 66.0 years; 70% Asian, 26% white, and 2.6% African American) were included. Fasting glucose level (FGL) during hospitalization was used to define 3 groups, T2D (FGL >= 7.0 mmol/L), impaired fasting glucose (FGL 6.1-6.9 mmol/L), and normal (FGL

Results-

Patients with T2D had significantly poorer performance in global cognition (SD, -0.59 [95% CI, -0.82 to -0.36]; P

Conclusions-

Diabetes mellitus, but not prediabetes, is associated with poorer cognitive performance in patients 3 to 6 months after stroke.

Original language	English
Pages (from-to)	1640-1646
Number of pages	7
Journal	Stroke
Volume	51
Issue number	6
DOIs	https://doi.org/10.1161/strokeaha.119.028428
Publication status	Published - Jun 2020

Keywords

cognition
diabetes mellitus
prediabetic state
stroke
IMPAIRED FASTING GLUCOSE
BLOOD-GLUCOSE
RISK-FACTORS
DECLINE
COMMUNITY
DEMENTIA
MELLITUS

Access to Document

10.1161/strokeaha.119.028428

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Cite this

Lo, J. W., Crawford, J. D., Samaras, K., Desmond, D. W., Kohler, S., Staals, J., Verhey, F. R. J., Bae, H.-J., Lee, K.-J., Kim, B. J., Bordet, R., Cordonnier, C., Dondaine, T., Mendyk, A.-M., Lee, B.-C., Yu, K.-H., Lim, J.-S., Kandiah, N., Chander, R. J., ... STROKOG Collaboration (2020). Association of Prediabetes and Type 2 Diabetes With Cognitive Function After Stroke: A STROKOG Collaboration Study. Stroke, 51(6), 1640-1646. https://doi.org/10.1161/strokeaha.119.028428

@article{d9e5b1dca3a942f8be8acd793fa87e71,

title = "Association of Prediabetes and Type 2 Diabetes With Cognitive Function After Stroke: A STROKOG Collaboration Study",

abstract = "Background and Purpose-Type 2 diabetes mellitus (T2D) is associated with cognitive impairment and an increased risk of dementia, but the association between prediabetes and cognitive impairment is less clear, particularly in a setting of major cerebrovascular events. This article examines the impact of impaired fasting glucose and T2D on cognitive performance in a stroke population.Methods-Seven international observational studies from the STROKOG (Stroke and Cognition) consortium (n=1601; mean age, 66.0 years; 70% Asian, 26% white, and 2.6% African American) were included. Fasting glucose level (FGL) during hospitalization was used to define 3 groups, T2D (FGL >= 7.0 mmol/L), impaired fasting glucose (FGL 6.1-6.9 mmol/L), and normal (FGLResults-Patients with T2D had significantly poorer performance in global cognition (SD, -0.59 [95% CI, -0.82 to -0.36]; PConclusions-Diabetes mellitus, but not prediabetes, is associated with poorer cognitive performance in patients 3 to 6 months after stroke.",

keywords = "cognition, diabetes mellitus, prediabetic state, stroke, IMPAIRED FASTING GLUCOSE, BLOOD-GLUCOSE, RISK-FACTORS, DECLINE, COMMUNITY, DEMENTIA, MELLITUS",

author = "Lo, {Jessica W.} and Crawford, {John D.} and Katherine Samaras and Desmond, {David W.} and Sebastian Kohler and Julie Staals and Verhey, {Frans R. J.} and Hee-Joon Bae and Keon-Joo Lee and Kim, {Beom Joon} and Regis Bordet and Charlotte Cordonnier and Thibaut Dondaine and Anne-Marie Mendyk and Byung-Chul Lee and Kyung-Ho Yu and Jae-Sung Lim and Nagaendran Kandiah and Chander, {Russell J.} and Chathuri Yatawara and Lipnicki, {Darren M.} and Sachdev, {Perminder S.} and {STROKOG Collaboration}",

note = "Publisher Copyright: {\textcopyright} 2020 American Heart Association, Inc.",

year = "2020",

month = jun,

doi = "10.1161/strokeaha.119.028428",

language = "English",

volume = "51",

pages = "1640--1646",

journal = "Stroke",

issn = "0039-2499",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "6",

}

Lo, JW, Crawford, JD, Samaras, K, Desmond, DW, Kohler, S , Staals, J , Verhey, FRJ, Bae, H-J, Lee, K-J, Kim, BJ, Bordet, R, Cordonnier, C, Dondaine, T, Mendyk, A-M, Lee, B-C, Yu, K-H, Lim, J-S, Kandiah, N, Chander, RJ, Yatawara, C, Lipnicki, DM, Sachdev, PS & STROKOG Collaboration 2020, 'Association of Prediabetes and Type 2 Diabetes With Cognitive Function After Stroke: A STROKOG Collaboration Study', Stroke, vol. 51, no. 6, pp. 1640-1646. https://doi.org/10.1161/strokeaha.119.028428

TY - JOUR

T1 - Association of Prediabetes and Type 2 Diabetes With Cognitive Function After Stroke

T2 - A STROKOG Collaboration Study

AU - Lo, Jessica W.

AU - Crawford, John D.

AU - Samaras, Katherine

AU - Desmond, David W.

AU - Kohler, Sebastian

AU - Staals, Julie

AU - Verhey, Frans R. J.

AU - Bae, Hee-Joon

AU - Lee, Keon-Joo

AU - Kim, Beom Joon

AU - Bordet, Regis

AU - Cordonnier, Charlotte

AU - Dondaine, Thibaut

AU - Mendyk, Anne-Marie

AU - Lee, Byung-Chul

AU - Yu, Kyung-Ho

AU - Lim, Jae-Sung

AU - Kandiah, Nagaendran

AU - Chander, Russell J.

AU - Yatawara, Chathuri

AU - Lipnicki, Darren M.

AU - Sachdev, Perminder S.

AU - STROKOG Collaboration

PY - 2020/6

Y1 - 2020/6

N2 - Background and Purpose-Type 2 diabetes mellitus (T2D) is associated with cognitive impairment and an increased risk of dementia, but the association between prediabetes and cognitive impairment is less clear, particularly in a setting of major cerebrovascular events. This article examines the impact of impaired fasting glucose and T2D on cognitive performance in a stroke population.Methods-Seven international observational studies from the STROKOG (Stroke and Cognition) consortium (n=1601; mean age, 66.0 years; 70% Asian, 26% white, and 2.6% African American) were included. Fasting glucose level (FGL) during hospitalization was used to define 3 groups, T2D (FGL >= 7.0 mmol/L), impaired fasting glucose (FGL 6.1-6.9 mmol/L), and normal (FGLResults-Patients with T2D had significantly poorer performance in global cognition (SD, -0.59 [95% CI, -0.82 to -0.36]; PConclusions-Diabetes mellitus, but not prediabetes, is associated with poorer cognitive performance in patients 3 to 6 months after stroke.

AB - Background and Purpose-Type 2 diabetes mellitus (T2D) is associated with cognitive impairment and an increased risk of dementia, but the association between prediabetes and cognitive impairment is less clear, particularly in a setting of major cerebrovascular events. This article examines the impact of impaired fasting glucose and T2D on cognitive performance in a stroke population.Methods-Seven international observational studies from the STROKOG (Stroke and Cognition) consortium (n=1601; mean age, 66.0 years; 70% Asian, 26% white, and 2.6% African American) were included. Fasting glucose level (FGL) during hospitalization was used to define 3 groups, T2D (FGL >= 7.0 mmol/L), impaired fasting glucose (FGL 6.1-6.9 mmol/L), and normal (FGLResults-Patients with T2D had significantly poorer performance in global cognition (SD, -0.59 [95% CI, -0.82 to -0.36]; PConclusions-Diabetes mellitus, but not prediabetes, is associated with poorer cognitive performance in patients 3 to 6 months after stroke.

KW - cognition

KW - diabetes mellitus

KW - prediabetic state

KW - stroke

KW - IMPAIRED FASTING GLUCOSE

KW - BLOOD-GLUCOSE

KW - RISK-FACTORS

KW - DECLINE

KW - COMMUNITY

KW - DEMENTIA

KW - MELLITUS

U2 - 10.1161/strokeaha.119.028428

DO - 10.1161/strokeaha.119.028428

M3 - Article

SN - 0039-2499

VL - 51

SP - 1640

EP - 1646

JO - Stroke

JF - Stroke

IS - 6

ER -