CYP2D6 and CYP2C19 genotyping in psychiatric patients on psychotropic medication in the former Dutch Antilles

Anne B. Koopmans; David J. Vinkers; Petra J. A. Gelan; Hans W. Hoek; Peter N. van Harten

doi:10.2217/pgs-2017-0011

CYP2D6 and CYP2C19 genotyping in psychiatric patients on psychotropic medication in the former Dutch Antilles

Anne B. Koopmans^*
, David J. Vinkers
, Petra J. A. Gelan
, Hans W. Hoek
, Peter N. van Harten

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Aim: This study was aimed to asses the prevalence of CYP2D6 and CYP2C19 polymorphisms in psychiatric patients and in volunteers from Dutch caribbean origin. Methods: In total, 435 individuals were genotyped for CYP2D6 and CYP2C19. Of these, 269 were psychiatric patients on psychotropic medication, living in Curacao and 166 were volunteers from the Dutch Caribbean population. Results: No differences in prevalence of alleles were found. Conclusion: Although prevalence of alleles appeared to be very different from African and Caucasian populations, the distribution into predicted phenotypes shows an equal distribution as in Caucasians.

Original language	English
Pages (from-to)	1003-1012
Number of pages	10
Journal	Pharmacogenomics
Volume	18
Issue number	10
DOIs	https://doi.org/10.2217/pgs-2017-0011
Publication status	Published - Jul 2017

Keywords

Caribbean
CYP2C19
CYP2D6
ethnicity
prevalence
psychiatry
DEBRISOQUINE 4-HYDROXYLASE CYP2D6
GENETIC POLYMORPHISMS
TARDIVE-DYSKINESIA
HEALTHY-VOLUNTEERS
COST-EFFECTIVENESS
ALLELE FREQUENCY
SCHIZOPHRENIA
CYTOCHROME-P450
PHARMACOGENETICS
IMPLEMENTATION

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title = "CYP2D6 and CYP2C19 genotyping in psychiatric patients on psychotropic medication in the former Dutch Antilles",

abstract = "Aim: This study was aimed to asses the prevalence of CYP2D6 and CYP2C19 polymorphisms in psychiatric patients and in volunteers from Dutch caribbean origin. Methods: In total, 435 individuals were genotyped for CYP2D6 and CYP2C19. Of these, 269 were psychiatric patients on psychotropic medication, living in Curacao and 166 were volunteers from the Dutch Caribbean population. Results: No differences in prevalence of alleles were found. Conclusion: Although prevalence of alleles appeared to be very different from African and Caucasian populations, the distribution into predicted phenotypes shows an equal distribution as in Caucasians.",

keywords = "Caribbean, CYP2C19, CYP2D6, ethnicity, prevalence, psychiatry, DEBRISOQUINE 4-HYDROXYLASE CYP2D6, GENETIC POLYMORPHISMS, TARDIVE-DYSKINESIA, HEALTHY-VOLUNTEERS, COST-EFFECTIVENESS, ALLELE FREQUENCY, SCHIZOPHRENIA, CYTOCHROME-P450, PHARMACOGENETICS, IMPLEMENTATION",

author = "Koopmans, \{Anne B.\} and Vinkers, \{David J.\} and Gelan, \{Petra J. A.\} and Hoek, \{Hans W.\} and \{van Harten\}, \{Peter N.\}",

year = "2017",

month = jul,

doi = "10.2217/pgs-2017-0011",

language = "English",

volume = "18",

pages = "1003--1012",

journal = "Pharmacogenomics",

issn = "1462-2416",

publisher = "Routledge/Taylor \& Francis Group",

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T1 - CYP2D6 and CYP2C19 genotyping in psychiatric patients on psychotropic medication in the former Dutch Antilles

AU - Koopmans, Anne B.

AU - Vinkers, David J.

AU - Gelan, Petra J. A.

AU - Hoek, Hans W.

AU - van Harten, Peter N.

PY - 2017/7

Y1 - 2017/7

N2 - Aim: This study was aimed to asses the prevalence of CYP2D6 and CYP2C19 polymorphisms in psychiatric patients and in volunteers from Dutch caribbean origin. Methods: In total, 435 individuals were genotyped for CYP2D6 and CYP2C19. Of these, 269 were psychiatric patients on psychotropic medication, living in Curacao and 166 were volunteers from the Dutch Caribbean population. Results: No differences in prevalence of alleles were found. Conclusion: Although prevalence of alleles appeared to be very different from African and Caucasian populations, the distribution into predicted phenotypes shows an equal distribution as in Caucasians.

AB - Aim: This study was aimed to asses the prevalence of CYP2D6 and CYP2C19 polymorphisms in psychiatric patients and in volunteers from Dutch caribbean origin. Methods: In total, 435 individuals were genotyped for CYP2D6 and CYP2C19. Of these, 269 were psychiatric patients on psychotropic medication, living in Curacao and 166 were volunteers from the Dutch Caribbean population. Results: No differences in prevalence of alleles were found. Conclusion: Although prevalence of alleles appeared to be very different from African and Caucasian populations, the distribution into predicted phenotypes shows an equal distribution as in Caucasians.

KW - Caribbean

KW - CYP2C19

KW - CYP2D6

KW - ethnicity

KW - prevalence

KW - psychiatry

KW - DEBRISOQUINE 4-HYDROXYLASE CYP2D6

KW - GENETIC POLYMORPHISMS

KW - TARDIVE-DYSKINESIA

KW - HEALTHY-VOLUNTEERS

KW - COST-EFFECTIVENESS

KW - ALLELE FREQUENCY

KW - SCHIZOPHRENIA

KW - CYTOCHROME-P450

KW - PHARMACOGENETICS

KW - IMPLEMENTATION

U2 - 10.2217/pgs-2017-0011

DO - 10.2217/pgs-2017-0011

M3 - Article

C2 - 28639468

SN - 1462-2416

VL - 18

SP - 1003

EP - 1012

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 10

ER -

CYP2D6 and CYP2C19 genotyping in psychiatric patients on psychotropic medication in the former Dutch Antilles

Abstract

Keywords

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