CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study

Raffaele Altara; Marco Manca; Marleen H. Hessel; Yumei Gu; Laura C. van Vark; K. Martijn Akkerhuis; Jan A. Staessen; H. Struyker Boudier; George W. Booz; Matthijs Blankesteijn

doi:10.1007/s12265-016-9703-3

CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study

Raffaele Altara^*
, Marco Manca
, Marleen H. Hessel
, Yumei Gu
, Laura C. van Vark
, K. Martijn Akkerhuis
, Jan A. Staessen
, H. Struyker Boudier
, George W. Booz
, Matthijs Blankesteijn

^*Corresponding author for this work

Farmacologie en Toxicologie

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Chemokines are involved in the remodeling of the heart; however, their significance as biomarkers in heart failure is unknown. We observed that circulating CXCR3 receptor chemokines CXCL9 and CXCL10 in a rat model of heart failure were increased 1 week after myocardial infarction. CXCL10 was also increased in both remote and infarcted regions of the heart and remained elevated at 16 weeks; CXCL9 was elevated in the remote area at 1 week. In humans, hierarchical clustering and principal component analysis revealed that circulating CXCL10, MIP-1 alpha, and CD40 ligand were the best indicators for differentiating healthy and heart failure subjects. Serum CXCL10 levels were increased in patients with symptomatic heart failure as indexed by NYHA classification II through IV. The presence of CXCL10, MIP-1 alpha, and CD40 ligand appears to be dominant in patients with advanced heart failure. These findings identify a distinct profile of inflammatory mediators in heart failure patients.

Original language	English
Pages (from-to)	302-314
Number of pages	13
Journal	Journal of Cardiovascular Translational Research
Volume	9
Issue number	4
DOIs	https://doi.org/10.1007/s12265-016-9703-3
Publication status	Published - Aug 2016

Keywords

Chemokines
Inflammation
Immune response
CXCR3

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title = "CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study",

abstract = "Chemokines are involved in the remodeling of the heart; however, their significance as biomarkers in heart failure is unknown. We observed that circulating CXCR3 receptor chemokines CXCL9 and CXCL10 in a rat model of heart failure were increased 1 week after myocardial infarction. CXCL10 was also increased in both remote and infarcted regions of the heart and remained elevated at 16 weeks; CXCL9 was elevated in the remote area at 1 week. In humans, hierarchical clustering and principal component analysis revealed that circulating CXCL10, MIP-1 alpha, and CD40 ligand were the best indicators for differentiating healthy and heart failure subjects. Serum CXCL10 levels were increased in patients with symptomatic heart failure as indexed by NYHA classification II through IV. The presence of CXCL10, MIP-1 alpha, and CD40 ligand appears to be dominant in patients with advanced heart failure. These findings identify a distinct profile of inflammatory mediators in heart failure patients.",

keywords = "Chemokines, Inflammation, Immune response, CXCR3",

author = "Raffaele Altara and Marco Manca and Hessel, \{Marleen H.\} and Yumei Gu and \{van Vark\}, \{Laura C.\} and Akkerhuis, \{K. Martijn\} and Staessen, \{Jan A.\} and \{Struyker Boudier\}, H. and Booz, \{George W.\} and Matthijs Blankesteijn",

year = "2016",

month = aug,

doi = "10.1007/s12265-016-9703-3",

language = "English",

volume = "9",

pages = "302--314",

journal = "Journal of Cardiovascular Translational Research",

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TY - JOUR

T1 - CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study

AU - Altara, Raffaele

AU - Manca, Marco

AU - Hessel, Marleen H.

AU - Gu, Yumei

AU - van Vark, Laura C.

AU - Akkerhuis, K. Martijn

AU - Staessen, Jan A.

AU - Struyker Boudier, H.

AU - Booz, George W.

AU - Blankesteijn, Matthijs

PY - 2016/8

Y1 - 2016/8

N2 - Chemokines are involved in the remodeling of the heart; however, their significance as biomarkers in heart failure is unknown. We observed that circulating CXCR3 receptor chemokines CXCL9 and CXCL10 in a rat model of heart failure were increased 1 week after myocardial infarction. CXCL10 was also increased in both remote and infarcted regions of the heart and remained elevated at 16 weeks; CXCL9 was elevated in the remote area at 1 week. In humans, hierarchical clustering and principal component analysis revealed that circulating CXCL10, MIP-1 alpha, and CD40 ligand were the best indicators for differentiating healthy and heart failure subjects. Serum CXCL10 levels were increased in patients with symptomatic heart failure as indexed by NYHA classification II through IV. The presence of CXCL10, MIP-1 alpha, and CD40 ligand appears to be dominant in patients with advanced heart failure. These findings identify a distinct profile of inflammatory mediators in heart failure patients.

AB - Chemokines are involved in the remodeling of the heart; however, their significance as biomarkers in heart failure is unknown. We observed that circulating CXCR3 receptor chemokines CXCL9 and CXCL10 in a rat model of heart failure were increased 1 week after myocardial infarction. CXCL10 was also increased in both remote and infarcted regions of the heart and remained elevated at 16 weeks; CXCL9 was elevated in the remote area at 1 week. In humans, hierarchical clustering and principal component analysis revealed that circulating CXCL10, MIP-1 alpha, and CD40 ligand were the best indicators for differentiating healthy and heart failure subjects. Serum CXCL10 levels were increased in patients with symptomatic heart failure as indexed by NYHA classification II through IV. The presence of CXCL10, MIP-1 alpha, and CD40 ligand appears to be dominant in patients with advanced heart failure. These findings identify a distinct profile of inflammatory mediators in heart failure patients.

KW - Chemokines

KW - Inflammation

KW - Immune response

KW - CXCR3

U2 - 10.1007/s12265-016-9703-3

DO - 10.1007/s12265-016-9703-3

M3 - Article

C2 - 27271043

SN - 1937-5387

VL - 9

SP - 302

EP - 314

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

IS - 4

ER -

CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study

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Keywords

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