Cut-off of the one-minute sit-to-stand test to detect functional impairment in people with chronic obstructive pulmonary disease

Sara Souto-Miranda, Joana Antão, Guilherme Rodrigues, Maria Aurora Mendes, Martijn A Spruit, Alda Marques*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


INTRODUCTION: The 6-minute walking test (6MWT) is a widely used measure to assess functional status of people with chronic obstructive pulmonary disease (COPD). However, it requires a long hallway and might be time-consuming. Other simple measures might be useful as a first screening tool. We explored the predictive ability of the 1-minute sit-to-stand test (1-min STS) in discriminating people with COPD with or without functional impairment.

METHODS: A receiver operating characteristics (ROC) curve analysis was performed. We determined a threshold for the 1-min STS to identify functional impairment based on different cut-offs of the 6MWT (300, 350, 400 and 450 m).

RESULTS: A total of 135 people with COPD were included. Except for the <450 m cut-off of the 6MWT, all other cut-offs identified 19.5 repetitions as the optimal cut-off point for the 1-min STS. All AUCs showed excellent discrimination (AUCs = 0.812-0.901). The best AUC (<300 m cut-off) had an outstanding discrimination (0.901; 95%CI: 0.84-0.96; other AUCs 0.812-0.836) between people with or without functional impairment, with 86% specificity and 83% sensitivity.

CONCLUSION: A cut-off of 19.5 repetitions in the 1-min STS discriminates accurately people with COPD with a functional impairment. Future studies may validate our treatable trait candidate in other samples and investigate its utility in predicting other meaningful outcomes.

Original languageEnglish
Article number106892
Number of pages4
JournalRespiratory Medicine
Early online date22 May 2022
Publication statusPublished - Aug 2022


  • 1-minute sit-to-stand test
  • COPD
  • Cut-off
  • Treatable traits

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