Aktueller Therapiealgorithmus des intrahepatischen cholangiozellulären Karzinoms

Translated title of the contribution: Current Therapy Algorithm of Intrahepatic Cholangiocellular Carcinoma

G. Lurje, J. Bednarsch, C. Roderburg, C. Trautwein, U. P. Neumann*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Cholangiocarcinoma (CCC) is the second most common primary malignancy of the liver and is typically diagnosed at advanced disease stages. Among curative treatment options for CCC, radical surgical resection with extrahepatic bile duct resection, hepatectomy, and en-bloc lymphadenectomy are considered the mainstay of curative therapy. The assessment of the functional liver reserve by dynamic liver function tests and the estimation of the remaining future liver volume (future liver remnant, FLR) are of paramount importance. The introduction of novel interventional and surgical techniques, such as portal vein embolization, associating liver partition, and portal vein ligation for staged hepatectomy (ALPPS), have enabled clinicians to achieve resectability even in patients previously deemed unresectable. Radiofrequency ablation (RFA) shows acceptable results in small intrahepatic cholangiocarcinoma (IHCC) in liver cirrhosis and should be evaluated if cirrhosis precludes surgical treatment. Transarterial chemoembolization (TACE) or transarterial radioembolization (TARE) alone or in combination with systemic therapy may be applied in cases of surgical irresectability. According to recent results of the British BILCAP trial, adjuvant therapy may be considered after surgical resection in curative intent.
Translated title of the contributionCurrent Therapy Algorithm of Intrahepatic Cholangiocellular Carcinoma
Original languageGerman
Pages (from-to)858-864
Number of pages7
JournalDer Chirurg
Volume89
Issue number11
DOIs
Publication statusPublished - 1 Nov 2018

Keywords

  • Hepatectomy
  • Liver function test
  • Portal vein embolization
  • ALPPS
  • Lymphadenectomy
  • POSITRON-EMISSION-TOMOGRAPHY
  • LIVER-FUNCTION
  • RADIOFREQUENCY ABLATION
  • MANAGEMENT
  • BILIARY
  • MORTALITY
  • CHEMOTHERAPY
  • THERAPY
  • CANCERS
  • PATHOGENESIS

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