Current directions in non-invasive low intensity electric brain stimulation for depressive disorder

D.J. Schutter, A.T. Sack*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Non-invasive sub-convulsive stimulation of the human brain to improve depressive symptoms is increasingly finding its way in clinical settings as a viable form of somatic treatment. Following successful modulation of neural excitability with subsequent antidepressant effects, neural polarization by administrating weak direct currents to the scalp has gained renewed interest. A new wave of basic and clinical studies seems to underscore the potential therapeutic value of direct current stimulation in the treatment of depression. Issues concerning the lack of mechanistic insights into the workings of modifying brain function through neural polarization and how this process translates to its antidepressant properties calls for additional research. The range of its clinical applicability has yet to be established.
Original languageEnglish
Pages (from-to)945-952
JournalCns & Neurological Disorders-Drug Targets
Issue number6
Early online date25 Jun 2014
Publication statusPublished - 25 Jun 2014

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