Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation

Holger Garn; Sabine Bahn; Bernhard T. Baune; Elisabeth B. Binder; Hans Bisgaard; Talal A. Chatila; Triantafyllos Chavakis; Carsten Culmsee; Udo Dannlowski; Steffen Gay; James Gern; Tari Haahtela; Tilo Kircher; Ulf Mueller-Ladner; Markus F. Neurath; Klaus T. Preissner; Christoph Reinhardt; Graham Rook; Shannon Russell; Bernd Schmeck; Thaddeus Stappenbeck; Ulrich Steinhoff; Jim van Os; Scott Weiss; Michael Zemlin; Harald Renz

doi:10.1016/j.jaci.2016.02.046

Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation

Holger Garn, Sabine Bahn, Bernhard T. Baune, Elisabeth B. Binder, Hans Bisgaard, Talal A. Chatila, Triantafyllos Chavakis, Carsten Culmsee, Udo Dannlowski, Steffen Gay, James Gern, Tari Haahtela, Tilo Kircher, Ulf Mueller-Ladner, Markus F. Neurath, Klaus T. Preissner, Christoph Reinhardt, Graham Rook, Shannon Russell, Bernd SchmeckThaddeus Stappenbeck, Ulrich Steinhoff, Jim van Os, Scott Weiss, Michael Zemlin, Harald Renz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Web of Science)

Abstract

Recent research indicates that chronic inflammatory diseases, including allergies and autoimmune and neuropsychiatric diseases, share common pathways of cellular and molecular dysregulation. It was the aim of the International von-Behring-Rontgen Symposium (October 16-18, 2014, in Marburg, Germany) to discuss recent developments in this field. These include a concept of biodiversity; the contribution of urbanization, lifestyle factors, and nutrition (eg, vitamin D); and new mechanisms of metabolic and immune dysregulation, such as extracellular and intracellular RNAs and cellular and mitochondrial stress. Epigenetic mechanisms contribute further to altered gene expression and therefore to the development of chronic inflammation. These novel findings provide the foundation for further development of preventive and therapeutic strategies.

Original language	English
Pages (from-to)	47-56
Journal	Journal of Allergy and Clinical Immunology
Volume	138
Issue number	1
DOIs	https://doi.org/10.1016/j.jaci.2016.02.046
Publication status	Published - Jul 2016

Keywords

Chronic inflammation
immune dysregulation
metabolism
environment
epigenetics
stress
biodiversity

Access to Document

10.1016/j.jaci.2016.02.046

Cite this

Garn, H., Bahn, S., Baune, B. T., Binder, E. B., Bisgaard, H., Chatila, T. A., Chavakis, T., Culmsee, C., Dannlowski, U., Gay, S., Gern, J., Haahtela, T., Kircher, T., Mueller-Ladner, U., Neurath, M. F., Preissner, K. T., Reinhardt, C., Rook, G., Russell, S., ... Renz, H. (2016). Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation. Journal of Allergy and Clinical Immunology, 138(1), 47-56. https://doi.org/10.1016/j.jaci.2016.02.046

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title = "Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation",

abstract = "Recent research indicates that chronic inflammatory diseases, including allergies and autoimmune and neuropsychiatric diseases, share common pathways of cellular and molecular dysregulation. It was the aim of the International von-Behring-Rontgen Symposium (October 16-18, 2014, in Marburg, Germany) to discuss recent developments in this field. These include a concept of biodiversity; the contribution of urbanization, lifestyle factors, and nutrition (eg, vitamin D); and new mechanisms of metabolic and immune dysregulation, such as extracellular and intracellular RNAs and cellular and mitochondrial stress. Epigenetic mechanisms contribute further to altered gene expression and therefore to the development of chronic inflammation. These novel findings provide the foundation for further development of preventive and therapeutic strategies.",

keywords = "Chronic inflammation, immune dysregulation, metabolism, environment, epigenetics, stress, biodiversity",

author = "Holger Garn and Sabine Bahn and Baune, {Bernhard T.} and Binder, {Elisabeth B.} and Hans Bisgaard and Chatila, {Talal A.} and Triantafyllos Chavakis and Carsten Culmsee and Udo Dannlowski and Steffen Gay and James Gern and Tari Haahtela and Tilo Kircher and Ulf Mueller-Ladner and Neurath, {Markus F.} and Preissner, {Klaus T.} and Christoph Reinhardt and Graham Rook and Shannon Russell and Bernd Schmeck and Thaddeus Stappenbeck and Ulrich Steinhoff and {van Os}, Jim and Scott Weiss and Michael Zemlin and Harald Renz",

year = "2016",

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doi = "10.1016/j.jaci.2016.02.046",

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Garn, H, Bahn, S, Baune, BT, Binder, EB, Bisgaard, H, Chatila, TA, Chavakis, T, Culmsee, C, Dannlowski, U, Gay, S, Gern, J, Haahtela, T, Kircher, T, Mueller-Ladner, U, Neurath, MF, Preissner, KT, Reinhardt, C, Rook, G, Russell, S, Schmeck, B, Stappenbeck, T, Steinhoff, U, van Os, J, Weiss, S, Zemlin, M & Renz, H 2016, 'Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation', Journal of Allergy and Clinical Immunology, vol. 138, no. 1, pp. 47-56. https://doi.org/10.1016/j.jaci.2016.02.046

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AU - Garn, Holger

AU - Bahn, Sabine

AU - Baune, Bernhard T.

AU - Binder, Elisabeth B.

AU - Bisgaard, Hans

AU - Chatila, Talal A.

AU - Chavakis, Triantafyllos

AU - Culmsee, Carsten

AU - Dannlowski, Udo

AU - Gay, Steffen

AU - Gern, James

AU - Haahtela, Tari

AU - Kircher, Tilo

AU - Mueller-Ladner, Ulf

AU - Neurath, Markus F.

AU - Preissner, Klaus T.

AU - Reinhardt, Christoph

AU - Rook, Graham

AU - Russell, Shannon

AU - Schmeck, Bernd

AU - Stappenbeck, Thaddeus

AU - Steinhoff, Ulrich

AU - van Os, Jim

AU - Weiss, Scott

AU - Zemlin, Michael

AU - Renz, Harald

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N2 - Recent research indicates that chronic inflammatory diseases, including allergies and autoimmune and neuropsychiatric diseases, share common pathways of cellular and molecular dysregulation. It was the aim of the International von-Behring-Rontgen Symposium (October 16-18, 2014, in Marburg, Germany) to discuss recent developments in this field. These include a concept of biodiversity; the contribution of urbanization, lifestyle factors, and nutrition (eg, vitamin D); and new mechanisms of metabolic and immune dysregulation, such as extracellular and intracellular RNAs and cellular and mitochondrial stress. Epigenetic mechanisms contribute further to altered gene expression and therefore to the development of chronic inflammation. These novel findings provide the foundation for further development of preventive and therapeutic strategies.

AB - Recent research indicates that chronic inflammatory diseases, including allergies and autoimmune and neuropsychiatric diseases, share common pathways of cellular and molecular dysregulation. It was the aim of the International von-Behring-Rontgen Symposium (October 16-18, 2014, in Marburg, Germany) to discuss recent developments in this field. These include a concept of biodiversity; the contribution of urbanization, lifestyle factors, and nutrition (eg, vitamin D); and new mechanisms of metabolic and immune dysregulation, such as extracellular and intracellular RNAs and cellular and mitochondrial stress. Epigenetic mechanisms contribute further to altered gene expression and therefore to the development of chronic inflammation. These novel findings provide the foundation for further development of preventive and therapeutic strategies.

KW - Chronic inflammation

KW - immune dysregulation

KW - metabolism

KW - environment

KW - epigenetics

KW - stress

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DO - 10.1016/j.jaci.2016.02.046

M3 - Article

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JO - Journal of Allergy and Clinical Immunology

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