CtHPV-DNA-basierte Präzisionsonkologie für Patienten mit Oropharynxkarzinom - wo stehen wir?

Translated title of the contribution: CtHPV-DNA based precision oncology for patients with oropharyngeal cancer Where are we?

Nora Wuerdemann*, Simon Joosse, Charlotte Klasen, Johanna Prinz, Imke Demers, Julie George, Ernst-Jan Maria Speel, Steffen Wagner, Jens Peter Klussmann

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Human papillomavirus (HPV) is an established etiologic factor for cancers in the head and neck region, specifically for Oropharyngeal Squamous Cell Carcinoma (OPSCC). The comparatively good overall survival justifies the current discussion regarding therapy de-escalation for patients with a low-risk profile. In addition to the immunohistochemistry-based biomarker p16INK4a, there is still a need for diagnostic and prognostic biomarkers that allow risk stratification and monitoring during therapy and follow-up of these patients. In recent years, liquid biopsy, especially in the form of plasma samples, has gained importance and is already used to monitor viral DNA in patients with Epstein-Barr virus-associated nasopharyngeal carcinoma. Circulating DNA (ctDNA) released by the tumor into the bloodstream is particularly suitable for a high specificity in detecting virus-associated tumors. Detection of viral E6 and E7 oncogenes in HPV-positive OPSCC is predominantly performed by droplet digital/quantitative PCR as well as next generation sequencing. Detection of circulating HPV-DNA derived from tumor cells (ctHPV-DNA) at diagnosis is associated with advanced tumor stage, locoregional and distant metastases. Longitudinal studies have further demonstrated that detectable and/or increasing ctHPV-DNA levels are associated with treatment failure and disease relapse. However, a standardization of the diagnostic procedure is necessary before introducing liquid biopsy into the clinical routine. In the future, this might allow a valid reflection of disease progression in HPV-positive OPSCC.
Translated title of the contributionCtHPV-DNA based precision oncology for patients with oropharyngeal cancer Where are we?
Original languageGerman
Pages (from-to)728-734
Number of pages7
JournalLaryngo-Rhino-Otologie
Volume102
Issue number10
Early online date1 Jun 2023
DOIs
Publication statusPublished - Oct 2023

Keywords

  • human papillomavirus
  • head and neck squamous cell carcinoma
  • liquid biopsy
  • ctHPV-DNA
  • biomarker
  • oropharyngeal squamous cell carcinoma
  • HUMAN-PAPILLOMAVIRUS DNA
  • CELL-FREE DNA
  • HPV DNA
  • PLASMA
  • SURVEILLANCE
  • RECURRENCE
  • HEAD

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