CT-Guided Percutaneous Transthoracic Needle Biopsies Using 10G Large-Core Needles: Initial Experience

Ulrich C. Lalji, Joachim E. Wildberger, Axel Zur Hausen, Matyas Bendek, Anne-Marie C. Dingemans, Monique Hochstenbag, Marco Das*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Using large-core biopsy needles in CT-guided percutaneous transthoracic needle biopsies (PTNB) may be advantageous in terms of larger specimens, which facilitate more extensive histopathological, immunohistochemical, and molecular examination of tumor tissue. The aim of this study was to evaluate the success rate and safety in CT-guided PTNB using 10G large-core biopsy needles. 35 patients with intrathoracic lesions suspected of malignancy underwent CT-guided PTNB using dedicated large-core biopsy needles (10G Spirotome (TM), Medinvents, Hasselt, Belgium). Location, tumor size, number of pleural passes, number of biopsies, histologic result, and complications (pneumothorax, bleeding) were recorded. Lesion location varied from pleural to hilar location. Mean tumor size was 3.5 cm (range 0.7-9.2 cm). Only one pleural passage was necessary in all patients. Mean distance from the pleura to the lesion was 2.6 cm (max 9.2 cm). Large-core biopsy (10G) was successful in 88.6 %. Pneumothorax was found in 40 %. Minor intraparenchymal bleeding was present in 14 patients. No major complications were recorded. Large-core biopsy with 10G did not show higher complication rates compared to literature. It is technically feasible and safe. The obtained larger specimens may especially be helpful for the increasing demands of extensive molecular analysis for stratified patient care.
Original languageEnglish
Pages (from-to)1603-1610
JournalCardiovascular and Interventional Radiology
Issue number6
Publication statusPublished - Dec 2015


  • Image-guided biopsy
  • Large-core needle
  • Biopsy
  • Computed tomography (CT)
  • Interventional radiology
  • Lung neoplasms
  • Pneumothorax

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