CT-derived muscle remodelling after bronchoscopic lung volume reduction in advanced emphysema

Karin J. C. Sanders, Karin Klooster, Lowie E. G. W. Vanfleteren, Dirk-Jan Slebos, Annemie M. W. J. Schols*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)
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Muscle wasting frequently occurs in severe emphysema. Improving respiratory mechanics by bronchoscopic lung volume reduction using endobronchial valves (EBV) might prevent further loss or even increase in muscle mass. CT-derived skeletal muscle mass gain was observed in 39/49 patients 6 months after EBV. Multiple linear regression showed that gain in muscle (beta=2.4; 95% CI 0.2 to 4.6; p=0.036) and intramuscular fat (beta=3.1; 95% CI 0.2 to 5.9; p=0.035) is associated with improved 6 min walk distance independent of the change in residual volume. Skeletal muscle remodelling associates with improved exercise capacity after EBV, independent of hyperinflation reduction.

Original languageEnglish
Pages (from-to)206-207
Number of pages2
Issue number2
Publication statusPublished - Feb 2019



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