CT-derived muscle remodelling after bronchoscopic lung volume reduction in advanced emphysema

Karin J. C. Sanders, Karin Klooster, Lowie E. G. W. Vanfleteren, Dirk-Jan Slebos, Annemie M. W. J. Schols*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)
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Abstract

Muscle wasting frequently occurs in severe emphysema. Improving respiratory mechanics by bronchoscopic lung volume reduction using endobronchial valves (EBV) might prevent further loss or even increase in muscle mass. CT-derived skeletal muscle mass gain was observed in 39/49 patients 6 months after EBV. Multiple linear regression showed that gain in muscle (beta=2.4; 95% CI 0.2 to 4.6; p=0.036) and intramuscular fat (beta=3.1; 95% CI 0.2 to 5.9; p=0.035) is associated with improved 6 min walk distance independent of the change in residual volume. Skeletal muscle remodelling associates with improved exercise capacity after EBV, independent of hyperinflation reduction.

Original languageEnglish
Pages (from-to)206-207
Number of pages2
JournalThorax
Volume74
Issue number2
DOIs
Publication statusPublished - Feb 2019

Keywords

  • PHYSICAL-ACTIVITY
  • SKELETAL-MUSCLE
  • SURGERY

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