Cross-talk between macro- and microcirculation

Michel E. Safar*, H. A. Struijker-Boudier

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Physiologically, macro- and microcirculation differ markedly as macrocirculation deals with pulsatile pressure and flow and microcirculation with steady pressure and flow. Various such haemodynamic aspects correspond to a large heterogeneity in the structure and function of the vascular tree. In the past, diseases such as hypertension and diabetes mellitus were classified on the basis of the structure and function of small and large arteries. The purpose of this paper is to review the cross-talk between the micro- and macrocirculation. We shall discuss this cross-talk from the perspective of the development, physiology and pathology of the entire arterial tree.
Original languageEnglish
Pages (from-to)417-430
JournalActa Physiologica
Issue number4
Publication statusPublished - Apr 2010


  • macrocirculation
  • microcirculation
  • pulse wave reflection

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