Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder: lessons from CNTNAP2, ADGRL3, and PARK2

Elisa Dalla Vecchia, Niall Mortimer, Viola S. Palladino, Sarah Kittel-Schneider, Klaus-Peter Lesch, Andreas Reif, Annette Schenck, William H. J. Norton*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Citations (Web of Science)

Abstract

Animal and cellular models are essential tools for all areas of biological research including neuroscience. Model systems can also be used to investigate the pathophysiology of psychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). In this review, we provide a summary of animal and cellular models for three genes linked to ADHD and ASD in human patients - CNTNAP2, ADGRL3, and PARK2. We also highlight the strengths and weaknesses of each model system. By bringing together behavioral and neurobiological data, we demonstrate how a cross-species approach can provide integrated insights into gene function and the pathogenesis of ADHD and ASD. The knowledge gained from transgenic models will be essential to discover and validate new treatment targets for these disorders.

Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalPsychiatric Genetics
Volume29
Issue number1
DOIs
Publication statusPublished - Feb 2019

Keywords

  • ADGRL3
  • attention-deficit/hyperactivity disorder
  • autism spectrum disorder
  • CNTNAP2
  • cross-species
  • Drosophila
  • human induced pluripotent stem cells
  • mouse
  • PARK2
  • zebrafish
  • DEFICIT-HYPERACTIVITY DISORDER
  • PLURIPOTENT STEM-CELLS
  • COPY-NUMBER VARIATION
  • GENOME-WIDE ANALYSIS
  • DOPAMINERGIC-NEURONS
  • PARKINSONS-DISEASE
  • MITOCHONDRIAL DYSFUNCTION
  • CANDIDATE GENE
  • BEHAVIORAL PHENOTYPES
  • ANTIDEPRESSANT USE

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