TY - JOUR
T1 - Cross-sectional associations between cardiac biomarkers, cognitive performance, and structural brain changes are modified by age
T2 - The Maastricht Study
AU - Veugen, Marja G. J.
AU - Henry, Ronald M. A.
AU - Brunner-La Rocca, Hans-Peter
AU - Dagnelie, Pieter C.
AU - Schram, Miranda T.
AU - van Agtmaal, Marnix J. M.
AU - van der Kallen, Carla J. H.
AU - Sep, Simone J. S.
AU - van Boxtel, Martin P. J.
AU - Bekers, Otto
AU - Meex, Steven J. R.
AU - Jansen, Jacobus F. A.
AU - Kroon, Abraham A.
AU - Stehouwer, Coen D. A.
PY - 2018/8
Y1 - 2018/8
N2 - Objective NT-proBNP (N-terminal pro-B-type natriuretic peptide) and cardiac troponin T (cTNT) are associated with cognitive performance. Whether this extends to individualsApproach and Results In 3011 individuals (608 years; 49% women), NT-proBNP and cTNT, memory, information processing speed and executive functioning, grey matter (GM) and white matter, and white matter hyperintensity (WMH) volumes were determined. We used regression, adjusted for educational level, cardiovascular factors, and lifestyle factors, to test whether cross-sectional associations between biomarkers and cognitive performance and structural brain changes were modified by age (0.10). Higher cTNT was associated with greater WMH (0.18 [95% CI, -0.01 to 0.37]; P-interaction,>0.10) but not with GM (0.07 [95% CI, -6.87 to 7.02]; P-interaction,Conclusions Biomarkers of cardiac injury are continuously associated with structural brain changes in both older and younger individuals but with poorer cognitive performance only in older individuals. These findings stress the continuous nature of the heart-brain axis in the development of cognitive impairment.
AB - Objective NT-proBNP (N-terminal pro-B-type natriuretic peptide) and cardiac troponin T (cTNT) are associated with cognitive performance. Whether this extends to individualsApproach and Results In 3011 individuals (608 years; 49% women), NT-proBNP and cTNT, memory, information processing speed and executive functioning, grey matter (GM) and white matter, and white matter hyperintensity (WMH) volumes were determined. We used regression, adjusted for educational level, cardiovascular factors, and lifestyle factors, to test whether cross-sectional associations between biomarkers and cognitive performance and structural brain changes were modified by age (0.10). Higher cTNT was associated with greater WMH (0.18 [95% CI, -0.01 to 0.37]; P-interaction,>0.10) but not with GM (0.07 [95% CI, -6.87 to 7.02]; P-interaction,Conclusions Biomarkers of cardiac injury are continuously associated with structural brain changes in both older and younger individuals but with poorer cognitive performance only in older individuals. These findings stress the continuous nature of the heart-brain axis in the development of cognitive impairment.
KW - brain
KW - humans
KW - natriuretic peptide
KW - troponin T
KW - white matter
KW - SMALL VESSEL DISEASE
KW - NATRIURETIC PEPTIDE LEVELS
KW - HIGH CARDIOVASCULAR RISK
KW - OLDER-ADULTS
KW - TROPONIN-T
KW - GENERAL-POPULATION
KW - HEART-FAILURE
KW - BLOOD-PRESSURE
KW - ATHEROSCLEROSIS RISK
KW - TISSUE SEGMENTATION
U2 - 10.1161/ATVBAHA.118.311082
DO - 10.1161/ATVBAHA.118.311082
M3 - Article
SN - 1079-5642
VL - 38
SP - 1948
EP - 1958
JO - Arteriosclerosis Thrombosis and Vascular Biology
JF - Arteriosclerosis Thrombosis and Vascular Biology
IS - 8
ER -