TY - JOUR
T1 - Criteria for First-Year Growth Response to Growth Hormone Treatment in Prepubertal Children With Growth Hormone Deficiency
T2 - Do They Predict Poor Adult Height Outcome?
AU - Straetemans, Saartje
AU - De Schepper, Jean
AU - Thomas, Muriel
AU - Tenoutasse, Sylvie
AU - Beauloye, Veronique
AU - Rooman, Raoul
N1 - Funding Information:
This study was supported by a research grant from the BElgian Society for PEdiatric Endocrinology and Diabetology (BESPEED).
Funding Information:
We would like to thank Franciska Verlinde, Christine Derycke, and Fr?d?rique Schwilden for their help in data collection. In addition to the authors, the following investigators contributed to the Belgian Register for the Study of Growth and Puberty Problems: A. France, H. Dotremont, M. Den Brinker (University Hospital Antwerp), M. Cools, K. De Waele, M. Craen, S. Van Aken, S. van der Straaten (University Hospital Ghent), I. Gies, J. Vanbesien (University Hospital Brussels), J. P. Bourguignon, M. C. Lebrethon, A. S. Parent (University Hospital Li?ge), C. Heinrichs, ST, C. Brachet, E. Boros (H?pital Universitaire des Enfants Reine Fabiola, HUDERF, Brussels), M. Maes, VB, P. Lysy (University Hospital Saint-Luc, Brussels), G. Massa, R. Zeevaert (Jessa Hospital, Hasselt), F. de Zegher, I. Francois, D. Beckers, M. Van Helvoirt, K. Casteels (University Hospital Leuven), D. Beckers, T. Mouraux (CHU UCL Mont Godinne), K. Logghe (Delta Hospital Roeselare), O. Chivu (CHC Esp?rance, Montegn?e), S. Depoorter (AZ St. Jan Brugge). Funding. This study was supported by a research grant from the BElgian Society for PEdiatric Endocrinology and Diabetology (BESPEED).
Publisher Copyright:
© Copyright © 2019 Straetemans, De Schepper, Thomas, Tenoutasse, Beauloye and Rooman.
PY - 2019/11/26
Y1 - 2019/11/26
N2 - Objective: Several criteria for first-year growth response (FYGR) to growth hormone (GH) treatment have been proposed. We explored which FYGR criteria predicted best the final height outcome after GH treatment in prepubertal children with GH deficiency (GHD). Design and methods: Height data of 129 GHD children (83 boys) who attained adult height and had been treated with GH for at least 4 consecutive years with at least 1 year before pubertal onset, were retrieved from the Belgian GH Registry. The FYGR parameters were: (1) increase in height (Delta Ht) SDS, (2) height velocity (HV) SDS, (3) Delta HV (cm/year), (4) index of responsiveness (IoR) in KIGS prediction models, (5) first-year HV SDS based on the KIGS expected HV curve (HV KIGS SDS), (6) near final adult height (nFAH) prediction after first-year GH treatment. Poor final height outcome (PFHO) criteria were: (1) total Delta Ht SDS
AB - Objective: Several criteria for first-year growth response (FYGR) to growth hormone (GH) treatment have been proposed. We explored which FYGR criteria predicted best the final height outcome after GH treatment in prepubertal children with GH deficiency (GHD). Design and methods: Height data of 129 GHD children (83 boys) who attained adult height and had been treated with GH for at least 4 consecutive years with at least 1 year before pubertal onset, were retrieved from the Belgian GH Registry. The FYGR parameters were: (1) increase in height (Delta Ht) SDS, (2) height velocity (HV) SDS, (3) Delta HV (cm/year), (4) index of responsiveness (IoR) in KIGS prediction models, (5) first-year HV SDS based on the KIGS expected HV curve (HV KIGS SDS), (6) near final adult height (nFAH) prediction after first-year GH treatment. Poor final height outcome (PFHO) criteria were: (1) total Delta Ht SDS
KW - growth hormone treatment
KW - growth hormone deficiency
KW - children
KW - first-year growth response criteria
KW - adult height outcome
KW - IDIOPATHIC GH DEFICIENCY
KW - FINAL HEIGHT
KW - STANDARDS
KW - THERAPY
KW - BIRTH
KW - AGE
U2 - 10.3389/fendo.2019.00792
DO - 10.3389/fendo.2019.00792
M3 - Article
C2 - 31849835
SN - 1664-2392
VL - 10
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
M1 - 792
ER -