Creeping Proteins in Microporous Structures: Polymer Brush-Assisted Fabrication of 3D Gradients for Tissue Engineering

Michel Klein Gunnewiek; Andrea Di Luca; Hermannes Z. Bollemaat; Clemens A. van Blitterswijk; G. Julius Vancso; Lorenzo Moroni; Edmondo M. Benetti

doi:10.1002/adhm.201400797

Creeping Proteins in Microporous Structures: Polymer Brush-Assisted Fabrication of 3D Gradients for Tissue Engineering

Michel Klein Gunnewiek, Andrea Di Luca, Hermannes Z. Bollemaat, Clemens A. van Blitterswijk, G. Julius Vancso, Lorenzo Moroni^*, Edmondo M. Benetti

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Coupling of rapid prototyping techniques and surface-confined polymerizations allows the fabrication of 3D multidirectional gradients of biomolecules within microporous scaffolds. The compositional gradients can be tailored by polymer-brush-assisted diffusion of protein solutions. This technique allows spatial control over stem cells manipulation within 3D environments. ? 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Pages (from-to)	1169-1174
Journal	Advanced Healthcare Materials
Volume	4
Issue number	8
DOIs	https://doi.org/10.1002/adhm.201400797
Publication status	Published - 3 Jun 2015

Keywords

3D scaffolds
poly(epsilon-caprolactone)
polymer brushes
protein gradients
wetting

Access to Document

10.1002/adhm.201400797

Full TextFinal published version, 0.99 MBLicence: Taverne

Cite this

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title = "Creeping Proteins in Microporous Structures: Polymer Brush-Assisted Fabrication of 3D Gradients for Tissue Engineering",

abstract = "Coupling of rapid prototyping techniques and surface-confined polymerizations allows the fabrication of 3D multidirectional gradients of biomolecules within microporous scaffolds. The compositional gradients can be tailored by polymer-brush-assisted diffusion of protein solutions. This technique allows spatial control over stem cells manipulation within 3D environments. ? 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

keywords = "3D scaffolds, poly(epsilon-caprolactone), polymer brushes, protein gradients, wetting",

author = "Gunnewiek, {Michel Klein} and {Di Luca}, Andrea and Bollemaat, {Hermannes Z.} and {van Blitterswijk}, {Clemens A.} and Vancso, {G. Julius} and Lorenzo Moroni and Benetti, {Edmondo M.}",

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AU - Gunnewiek, Michel Klein

AU - Di Luca, Andrea

AU - Bollemaat, Hermannes Z.

AU - van Blitterswijk, Clemens A.

AU - Vancso, G. Julius

AU - Moroni, Lorenzo

AU - Benetti, Edmondo M.

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KW - 3D scaffolds

KW - poly(epsilon-caprolactone)

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KW - protein gradients

KW - wetting

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