Coupling of rapid prototyping techniques and surface-confined polymerizations allows the fabrication of 3D multidirectional gradients of biomolecules within microporous scaffolds. The compositional gradients can be tailored by polymer-brush-assisted diffusion of protein solutions. This technique allows spatial control over stem cells manipulation within 3D environments. ? 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
|Journal||Advanced Healthcare Materials|
|Publication status||Published - 3 Jun 2015|
- 3D scaffolds
- polymer brushes
- protein gradients