TY - JOUR
T1 - COVID-19 through Adverse Outcome Pathways
T2 - Building networks to better understand the disease - 3rd CIAO AOP Design Workshop
AU - Clerbaux, Laure-Alix
AU - Amigó, Núria
AU - Amorim, Maria João
AU - Bal-Price, Anna
AU - Batista Leite, Sofia
AU - Beronius, Anna
AU - Bezemer, Gillina F G
AU - Bostroem, Ann-Charlotte
AU - Carusi, Annamaria
AU - Coecke, Sandra
AU - Concha, Rachel
AU - Daskalopoulos, Evangelos P
AU - Debernardi, Francesca
AU - Edrosa, Eizleayne
AU - Edwards, Steve W
AU - Filipovska, Julija
AU - Garcia-Reyero, Natàlia
AU - Gavins, Felicity N E
AU - Halappanavar, Sabina
AU - Hargreaves, Alan J
AU - Hogberg, Helena T
AU - Huynh, Mylène T
AU - Jacobson, Daniel
AU - Josephs-Spaulding, Jonathan
AU - Kim, Young Jun
AU - Kong, Hyun Joon
AU - Krebs, Catharine E
AU - Lam, Ann
AU - Landesmann, Brigitte
AU - Layton, Adrienne
AU - Lee, Yong Oh
AU - Macmillan, Donna S
AU - Mantovani, Alberto
AU - Margiotta-Casaluci, Luigi
AU - Martens, Marvin
AU - Masereeuw, Rosalinde
AU - Mayasich, Sally A
AU - Mei, Liang Merlin
AU - Mortensen, Holly
AU - Munoz Pineiro, Amalia
AU - Nymark, Penny
AU - Ohayon, Elan
AU - Ojasi, Joshi
AU - Paini, Alicia
AU - Parissis, Nikolaos
AU - Parvatam, Surat
AU - Pistollato, Francesca
AU - Sachana, Magdalini
AU - Sørli, Jorid Birkelund
AU - Sullivan, Kristie M
AU - Sund, Jukka
AU - Tanabe, Shihori
AU - Tsaioun, Katya
AU - Vinken, Mathieu
AU - Viviani, Laura
AU - Waspe, Jennifer
AU - Willett, Catherine
AU - Wittwehr, Clemens
N1 - Funding Information:
The CIAO project is steered by the Joint Research Centre of the European Commission (EC-JRC), the Humane Society International (HSI), and the Physicians Committee for Responsible Medicine (PCRM). For Jorid Birkelund Sørli, the research is supported by FIKA, Focused Research Effort on Chemicals in the Working Environment from the Danish Government. For Daniel Jacobson, this work was supported by the Laboratory Directed Research and Development Program of Oak Ridge National Laboratory, managed by UT-Battelle, LLC for the US Department of Energy (LOIS:10074) and the National Institutes of Health 3RF1AG053303-01S2.
Funding Information:
Institutional Statement: This manuscript has been coauthored by UT-Battelle, LLC under Contract No. DE-AC05-00OR22725 with the U.S. Department of Energy. The United States Government retains and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes. The Department of Energy will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/ downloads/doe-public-access-plan).
Publisher Copyright:
© 2022 ALTEX Edition. All rights reserved.
PY - 2022
Y1 - 2022
N2 - On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project "Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework" aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome, such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed, as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating viral variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.
AB - On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project "Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework" aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome, such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed, as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating viral variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.
U2 - 10.14573/altex.2112161
DO - 10.14573/altex.2112161
M3 - Article
C2 - 35032963
SN - 1868-596X
VL - 39
SP - 322
EP - 335
JO - Altex-Alternatives To Animal Experimentation
JF - Altex-Alternatives To Animal Experimentation
IS - 2
ER -