Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN Study Rationale and Protocol

Rosa Maria Bruno*, Bart Spronck, Bernhard Hametner, Alun Hughes, Patrick Lacolley, Christopher C. Mayer, Maria Lorenza Muiesan, Chakravarthi Rajkumar, Dimitrios Terentes-Printzios, Thomas Weber, Tine Willum Hansen, Pierre Boutouyrie, Association for Research into Arterial Structure, Physiology (ARTERY) Society

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Web of Science)

Abstract

In December 2019, an outbreak of pneumonia caused by a novel Coronavirus (COVID-19) spread rapidly worldwide. Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, the cardiovascular system is extensively affected at multiple levels. Due to the unprecedented consequences of the COVID-19 pandemic, the ARTERY society decided to launch the Covid-19 effects on ARTErial StIffness and vascular AgeiNg (CARTESIAN) study - the first international multicentre study into the effects of COVID-19 on non-invasive biomarkers of vascular ageing. The main study objective is to evaluate the presence of Early Vascular Ageing (EVA) 6 and 12 months after COVID-19 infection. Secondary objectives are to study the effect of COVID-19 disease severity on EVA, to investigate the role of psychosocial factors in COVID-19 induced EVA, and to investigate the potential modifying effect of comorbidities and chronic treatments. In the CARTESIAN study, a broad array of cardiovascular measurements, including carotid-femoral pulse wave velocity, central blood pressure, carotid ultrasound, brachial flow-mediated dilatation, will be performed. To date, 43 centres from 21 countries have agreed to participate, with an expected study population of >2500 individuals. To our knowledge, CARTESIAN will be the first study to provide insight into the relationship between COVID-19, its severity, and early vascular ageing in a large cohort, potentially enabling future care and diagnostics to be more focused on the most vulnerable. (C) 2020 The Authors. Publishing services by Atlantis Press International B.V.

Original languageEnglish
Pages (from-to)59-68
Number of pages10
JournalArtery Research
Volume27
Issue number2
Early online date2020
DOIs
Publication statusPublished - Jun 2021

Keywords

  • ACUTE RESPIRATORY SYNDROME
  • AMERICAN SOCIETY
  • ANGIOTENSIN-II
  • AORTIC STIFFNESS
  • COVID-19
  • ECHOCARDIOGRAPHY
  • EUROPEAN ASSOCIATION
  • INFLAMMATION
  • ORGAN DAMAGE
  • PULSE-WAVE
  • THORACIC AORTA
  • arterial stiffness
  • coronavirus
  • inflammation
  • vascular ageing
  • DISEASE

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