TY - JOUR
T1 - Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN Study Rationale and Protocol
AU - Bruno, Rosa Maria
AU - Spronck, Bart
AU - Hametner, Bernhard
AU - Hughes, Alun
AU - Lacolley, Patrick
AU - Mayer, Christopher C.
AU - Muiesan, Maria Lorenza
AU - Rajkumar, Chakravarthi
AU - Terentes-Printzios, Dimitrios
AU - Weber, Thomas
AU - Hansen, Tine Willum
AU - Boutouyrie, Pierre
AU - Association for Research into Arterial Structure, Physiology (ARTERY) Society
PY - 2021/6
Y1 - 2021/6
N2 - In December 2019, an outbreak of pneumonia caused by a novel Coronavirus (COVID-19) spread rapidly worldwide. Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, the cardiovascular system is extensively affected at multiple levels. Due to the unprecedented consequences of the COVID-19 pandemic, the ARTERY society decided to launch the Covid-19 effects on ARTErial StIffness and vascular AgeiNg (CARTESIAN) study - the first international multicentre study into the effects of COVID-19 on non-invasive biomarkers of vascular ageing. The main study objective is to evaluate the presence of Early Vascular Ageing (EVA) 6 and 12 months after COVID-19 infection. Secondary objectives are to study the effect of COVID-19 disease severity on EVA, to investigate the role of psychosocial factors in COVID-19 induced EVA, and to investigate the potential modifying effect of comorbidities and chronic treatments. In the CARTESIAN study, a broad array of cardiovascular measurements, including carotid-femoral pulse wave velocity, central blood pressure, carotid ultrasound, brachial flow-mediated dilatation, will be performed. To date, 43 centres from 21 countries have agreed to participate, with an expected study population of >2500 individuals. To our knowledge, CARTESIAN will be the first study to provide insight into the relationship between COVID-19, its severity, and early vascular ageing in a large cohort, potentially enabling future care and diagnostics to be more focused on the most vulnerable. (C) 2020 The Authors. Publishing services by Atlantis Press International B.V.
AB - In December 2019, an outbreak of pneumonia caused by a novel Coronavirus (COVID-19) spread rapidly worldwide. Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, the cardiovascular system is extensively affected at multiple levels. Due to the unprecedented consequences of the COVID-19 pandemic, the ARTERY society decided to launch the Covid-19 effects on ARTErial StIffness and vascular AgeiNg (CARTESIAN) study - the first international multicentre study into the effects of COVID-19 on non-invasive biomarkers of vascular ageing. The main study objective is to evaluate the presence of Early Vascular Ageing (EVA) 6 and 12 months after COVID-19 infection. Secondary objectives are to study the effect of COVID-19 disease severity on EVA, to investigate the role of psychosocial factors in COVID-19 induced EVA, and to investigate the potential modifying effect of comorbidities and chronic treatments. In the CARTESIAN study, a broad array of cardiovascular measurements, including carotid-femoral pulse wave velocity, central blood pressure, carotid ultrasound, brachial flow-mediated dilatation, will be performed. To date, 43 centres from 21 countries have agreed to participate, with an expected study population of >2500 individuals. To our knowledge, CARTESIAN will be the first study to provide insight into the relationship between COVID-19, its severity, and early vascular ageing in a large cohort, potentially enabling future care and diagnostics to be more focused on the most vulnerable. (C) 2020 The Authors. Publishing services by Atlantis Press International B.V.
KW - ACUTE RESPIRATORY SYNDROME
KW - AMERICAN SOCIETY
KW - ANGIOTENSIN-II
KW - AORTIC STIFFNESS
KW - COVID-19
KW - ECHOCARDIOGRAPHY
KW - EUROPEAN ASSOCIATION
KW - INFLAMMATION
KW - ORGAN DAMAGE
KW - PULSE-WAVE
KW - THORACIC AORTA
KW - arterial stiffness
KW - coronavirus
KW - inflammation
KW - vascular ageing
KW - DISEASE
U2 - 10.2991/artres.k.201124.001
DO - 10.2991/artres.k.201124.001
M3 - Article
C2 - 35414837
VL - 27
SP - 59
EP - 68
JO - Artery Research
JF - Artery Research
SN - 1872-9312
IS - 2
ER -