Cost Evaluation of Dried Blood Spot Home Sampling as Compared to Conventional Sampling for Therapeutic Drug Monitoring in Children

Lisa C. Martial; Rob E. Aarnoutse; Michiel F. Schreuder; Stefanie S. Henriet; Roger J. M. Brueggemann; Manuela A. Joore

doi:10.1371/journal.pone.0167433

Cost Evaluation of Dried Blood Spot Home Sampling as Compared to Conventional Sampling for Therapeutic Drug Monitoring in Children

Lisa C. Martial^*, Rob E. Aarnoutse, Michiel F. Schreuder, Stefanie S. Henriet, Roger J. M. Brueggemann, Manuela A. Joore

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Dried blood spot (DBS) sampling for the purpose of therapeutic drug monitoring can be an attractive alternative for conventional blood sampling, especially in children. This study aimed to compare all costs involved in conventional sampling versus DBS home sampling in two pediatric populations: renal transplant patients and hemato-oncology patients. Total costs were computed from a societal perspective by adding up healthcare cost, patient related costs and costs related to loss of productivity of the caregiver. Switching to DBS home sampling was associated with a cost reduction of 43% for hemato-oncology patients ((sic)277 to (sic)158) and 61% for nephrology patients ((sic)259 to (sic)102) from a societal perspective (total costs) per blood draw. From a healthcare perspective, costs reduced with 7% for hemato-oncology patients and with 21% for nephrology patients. Total savings depend on the number of hospital visits that can be avoided by using home sampling instead of conventional sampling.

Original language	English
Article number	e0167433
Journal	PLOS ONE
Volume	11
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0167433
Publication status	Published - 12 Dec 2016

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10.1371/journal.pone.0167433Licence: CC BY

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title = "Cost Evaluation of Dried Blood Spot Home Sampling as Compared to Conventional Sampling for Therapeutic Drug Monitoring in Children",

abstract = "Dried blood spot (DBS) sampling for the purpose of therapeutic drug monitoring can be an attractive alternative for conventional blood sampling, especially in children. This study aimed to compare all costs involved in conventional sampling versus DBS home sampling in two pediatric populations: renal transplant patients and hemato-oncology patients. Total costs were computed from a societal perspective by adding up healthcare cost, patient related costs and costs related to loss of productivity of the caregiver. Switching to DBS home sampling was associated with a cost reduction of 43% for hemato-oncology patients ((sic)277 to (sic)158) and 61% for nephrology patients ((sic)259 to (sic)102) from a societal perspective (total costs) per blood draw. From a healthcare perspective, costs reduced with 7% for hemato-oncology patients and with 21% for nephrology patients. Total savings depend on the number of hospital visits that can be avoided by using home sampling instead of conventional sampling.",

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AU - Martial, Lisa C.

AU - Aarnoutse, Rob E.

AU - Schreuder, Michiel F.

AU - Henriet, Stefanie S.

AU - Brueggemann, Roger J. M.

AU - Joore, Manuela A.

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AB - Dried blood spot (DBS) sampling for the purpose of therapeutic drug monitoring can be an attractive alternative for conventional blood sampling, especially in children. This study aimed to compare all costs involved in conventional sampling versus DBS home sampling in two pediatric populations: renal transplant patients and hemato-oncology patients. Total costs were computed from a societal perspective by adding up healthcare cost, patient related costs and costs related to loss of productivity of the caregiver. Switching to DBS home sampling was associated with a cost reduction of 43% for hemato-oncology patients ((sic)277 to (sic)158) and 61% for nephrology patients ((sic)259 to (sic)102) from a societal perspective (total costs) per blood draw. From a healthcare perspective, costs reduced with 7% for hemato-oncology patients and with 21% for nephrology patients. Total savings depend on the number of hospital visits that can be avoided by using home sampling instead of conventional sampling.

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