Cost-Effectiveness Study of One-Stage Treatment of Chronic Osteomyelitis with Bioactive Glass S53P4

Jan Geurts*, Tom van Vugt, Eline Thijssen, Jacobus J. Arts

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)

Abstract

This study was set up to evaluate the costs of a one-stage treatment of chronic osteomyelitis using bioactive glass S53P4 versus a two-stage treatment using gentamicin-loaded PMMA beads. Furthermore, a cost-effectiveness analysis was performed from a hospital's perspective together with the evaluation of clinical outcome. A treatment group (n = 25) receiving one-stage surgery with bioactive glass was retrospectively compared with a two-stage control group (n = 25). An assessment was made of all costs included from first outpatient visit until one year after treatment. Bootstrap simulation and sensitivity analyses were performed. The primary endpoint was cost-effectiveness with clinical outcome as the secondary endpoint. The base case analyses shows dominance of the one-stage treatment with bioactive glass S53P4 due to lower costs and a better clinical outcome. Sensitivity analyses confirm these findings. This study is the first in its kind to show one-stage treatment of chronic osteomyelitis with bioactive glass S53P4 to be cost-effective.

Original languageEnglish
Article number3209
Number of pages11
JournalMaterials
Volume12
Issue number19
DOIs
Publication statusPublished - Oct 2019

Keywords

  • bioactive glass
  • osteomyelitis
  • cost-effectivity
  • PARENTERAL ANTIMICROBIAL THERAPY
  • CALCIUM-PHOSPHATE FORMATION
  • IN-VITRO
  • ECONOMIC-EVALUATION
  • HUMAN OSTEOBLASTS
  • JOINT INFECTIONS
  • NODULE FORMATION
  • IONIC PRODUCTS
  • BONE-FORMATION
  • BEHAVIOR

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