Cost-effectiveness of gastro-resistant risedronate tablets for the treatment of postmenopausal women with osteoporosis in France

M. Hiligsmann*, J. -Y. Reginster

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Web of Science)

Abstract

The SummaryThe use of gastro-resistant risedronate, a convenient dosing regimen for oral bisphosphonate therapy, seems a cost-effective strategy compared with weekly alendronate, generic risedronate, and no treatment for the treatment of postmenopausal women with osteoporosis in France.IntroductionGastro-resistant (GR) risedronate tablets are associated with improved persistence compared to common oral bisphosphonates but are slightly more expensive. This study assessed its cost-effectiveness compared to weekly alendronate and generic risedronate for the treatment of postmenopausal women with osteoporosis in France.MethodsA previously validated Markov microsimulation model was used to estimate the lifetime costs (expressed in Euro2017) per quality-adjusted life-years (QALY) of GR risedronate compared with weekly alendronate, generic risedronate, and no treatment. Pooled efficacy data for bisphosphonates derived from a previous meta-analysis were used for all treatment options, and persistence data (up to 3years) were obtained from a large Australian longitudinal study. Evaluation was done for high-risk women 60-80years of age, with a bone mineral density (BMD) T-score-2.5 and/or prevalent vertebral fractures.ResultsIn all of the simulated populations, GR risedronate was cost-effective compared to alendronate, generic risedronate, and no treatment at a threshold of Euro60,000 per QALY gained. In women with a BMD T-score-2.5 and prevalent vertebral fractures, the cost per QALY gained of GR risedronate compared to alendronate, generic risedronate, and no treatment falls below Euro20,000 per QALY gained. In women aged 75years and older, GR risedronate was even shown to be dominant (more QALYs, less costs) compared to alendronate, generic risedronate, and no treatment.ConclusionThis study provides the first economic results about GR risedronate, suggesting that it represents a cost-effective strategy compared with weekly alendronate and generic risedronate for the treatment of postmenopausal women with osteoporosis in France.

Original languageEnglish
Pages (from-to)649-658
Number of pages10
JournalOsteoporosis International
Volume30
Issue number3
DOIs
Publication statusPublished - Mar 2019

Keywords

  • Cost-effectiveness
  • Economic evaluation
  • Osteoporosis
  • Risedronate
  • Treatment
  • QUALITY-OF-LIFE
  • ECONOMIC-EVALUATION
  • INTERVENTION THRESHOLDS
  • ORAL BISPHOSPHONATES
  • EXCESS MORTALITY
  • HIP FRACTURE
  • PERSISTENCE
  • ADHERENCE
  • HOSPITALIZATION
  • BURDEN

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