Correlation of tumor size with other prognostic factors in uterine serous carcinoma: A large multi-institutional study

Ira S. Winer, Haider S. Mahdi, Sudeshna Bandyopadhyay, Assaad Semaan, K. K. Van de Vijver, Marisa R. Nucci, F. Abdul-Karim, Yaser Hussein, F. Qureshi, Kinda Hayek, Baraa Alosh, D. Schulz, Michele L. Cote, Adnan R. Munkarah, Richard Morris, Esther Oliva, Rouba Ali-Fehmi*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)

Abstract

Uterine serous carcinoma (USC) constitutes 10% of uterine cancers but ~40% of deaths. Tumor size is a known prognostic factor in other solid tumors. In endometriod cancers it is one element used to identify the need for complete staging, while its significance in USC is debated. Therefore tumor size was examined as an independent prognostic factor.Clinical and pathologic variables were recorded for 236 institutional patients, and those patients in the SEER database with USC. Chi-square and Fisher exact t-tests were utilized and survival data generated via Kaplan-Meier method; multivariate analysis was performed via cox-regression.The patients' mean age was 67.2 years (range 40-91). Survival ranged from 0 to 184 months (mean 42.8). We used a tumor size cut-off of 1cm and noted significant associations with myometrial invasion (p
Original languageEnglish
Pages (from-to)316-321
JournalGynecologic Oncology
Volume128
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Uterine serous carcinoma (USC)
  • Staging
  • Tumor size
  • Prognostic factors

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