Coronary heart disease and risk for cognitive impairment or dementia: Systematic review and meta-analysis

Kay Deckers*, Syenna H. J. Schievink, Maria M. F. Rodriquez, Robert J. van Oostenbrugge, Martin P. J. van Boxtel, Frans R. J. Verhey, Sebastian Kohler

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Aims/Hypothesis Accumulating evidence suggests an association between coronary heart disease and risk for cognitive impairment or dementia, but no study has systematically reviewed this association. Therefore, we summarized the available evidence on the association between coronary heart disease and risk for cognitive impairment or dementia. Methods Medline, Embase, PsycINFO, and CINAHL were searched for all publications until 8th January 2016. Articles were included if they fulfilled the inclusion criteria: (1) myocardial infarction, angina pectoris or coronary heart disease (combination of both) as predictor variable; (2) cognition, cognitive impairment or dementia as outcome; (3) population-based study; (4) prospective (>= 1 year follow-up), cross-sectional or case-control study design; (5) >= 100 participants; and (6) aged >= 45 years. Reference lists of publications and secondary literature were hand-searched for possible missing articles. Two reviewers independently screened all abstracts and extracted information from potential relevant full-text articles using a standardized data collection form. Study quality was assessed with the Newcastle-Ottawa Scale. We pooled estimates from the most fully adjusted model using random-effects meta-analysis. Results We identified 6,132 abstracts, of which 24 studies were included. A meta-analysis of 10 prospective cohort studies showed that coronary heart disease was associated with increased risk of cognitive impairment or dementia (OR = 1.45, 95% CI = 1.21-1.74, p
Original languageEnglish
Article numbere0184244
Issue number9
Publication statusPublished - 8 Sept 2017

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