Coronary-aortic interaction during ventricular isovolumic contraction

Marc J. van Houwelingen*, Daphne Merkus, Maaike Te Lintel Hekkert, Geert van Dijk, Arnold P. G. Hoeks, Dirk J. Duncker

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


In earlier work, we suggested that the start of the isovolumic contraction period could be detected in arterial pressure waveforms as the start of a temporary pre-systolic pressure perturbation (AIC(start), start of the Arterially detected Isovolumic Contraction), and proposed the retrograde coronary blood volume flow in combination with a backwards traveling pressure wave as its most likely origin. In this study, we tested this hypothesis by means of a coronary artery occlusion protocol. In six Yorkshire x Landrace swine, we simultaneously occluded the left anterior descending (LAD) and left circumflex (LCx) artery for 5 s followed by a 20-s reperfusion period and repeated this sequence at least two more times. A similar procedure was used to occlude only the right coronary artery (RCA) and finally all three main coronary arteries simultaneously. None of the occlusion protocols caused a decrease in the arterial pressure perturbation in the aorta during occlusion (P > 0.20) nor an increase during reactive hyperemia (P > 0.22), despite a higher deceleration of coronary blood volume flow (P = 0.03) or increased coronary conductance (P = 0.04) during hyperemia. These results show that the pre-systolic aortic pressure perturbation does not originate from the coronary arteries.
Original languageEnglish
Pages (from-to)917-924
JournalMedical & Biological Engineering & Computing
Issue number8
Publication statusPublished - Aug 2011


  • Isovolumic contraction
  • Coronary-aortic interaction
  • Coronary occlusion
  • Pulse wave analysis

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